MTHFR and MMP23B

Data Source:
BioGRID (affinity chromatography technology)

		MTHFR	MMP23B
Description		methylenetetrahydrofolate reductase	matrix metallopeptidase 23B
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Synapse	Extracellular Space Endoplasmic Reticulum Membrane Integral Component Of Membrane Extracellular Matrix Collagen-containing Extracellular Matrix
	Molecular Function	Methylenetetrahydrofolate Reductase (NAD(P)H) Activity Protein-containing Complex Binding Flavin Adenine Dinucleotide Binding NADP Binding FAD Binding Modified Amino Acid Binding	Metalloendopeptidase Activity Metallopeptidase Activity Zinc Ion Binding
	Biological Process	Response To Hypoxia Neural Tube Closure Methionine Metabolic Process Methionine Biosynthetic Process Regulation Of Histone Methylation Response To Vitamin B2 Tetrahydrofolate Interconversion Response To Drug Response To Amino Acid S-adenosylmethionine Metabolic Process Folic Acid Metabolic Process Homocysteine Metabolic Process Response To Folic Acid Response To Interleukin-1 Heterochromatin Maintenance	Reproduction Proteolysis Extracellular Matrix Organization Collagen Catabolic Process
Pathways		Metabolism of folate and pterines
Drugs		Cyanocobalamin Tetrahydrofolic acid	Marimastat
Diseases		Spina bifida Isolated orofacial clefts, including: Cleft lip with or without cleft palate; Cleft palate Homocystinuria
GWAS		Atrial fibrillation ( 19597492) Blood pressure ( 21909110) Coronary artery disease ( 29212778) Diastolic blood pressure ( 27841878 28739976 27618452 29615537) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Folate pathway vitamin levels ( 19744961) High altitude adaptation ( 28373541) Homocysteine levels ( 23824729 20031578 23696881) Hypertension ( 31879980) Mean arterial pressure ( 27618448) Mean corpuscular hemoglobin ( 32888494) Mean platelet volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (calcium channel blockers) ( 31015401) Midregional pro atrial natriuretic peptide levels ( 29237677) Moyamoya disease ( 29273593) Multiple sclerosis ( 31604244) Offspring birth weight ( 31043758) Plasma homocysteine levels ( 30339177) Pulse pressure ( 27841878) Red blood cell count ( 32888494) Red blood cell folate levels ( 30339177) Serum folate levels ( 30339177 29953918) Systolic blood pressure ( 19430483 27841878 28739976 27618447 27618452) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Tuberculosis ( 29036319)	Body mass index ( 26426971)
Interacting Genes		1 interacting genes: LSM8	2 interacting genes: GLRX SRPK2
Entrez ID		4524	8510
HPRD ID		06158	04503
Ensembl ID		ENSG00000177000	ENSG00000189409
Uniprot IDs		P42898 Q59GJ6 Q5SNW7 Q8IU67	O75900
PDB IDs		6FCX
Enriched GO Terms of Interacting Partners?
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