KMT2A and RDX

Data Source:
BioGRID (affinity chromatography technology)

		KMT2A	RDX
Description		lysine methyltransferase 2A	radixin
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Histone Methyltransferase Complex MLL1 Complex	Extracellular Space Plasma Membrane Microvillus Adherens Junction Focal Adhesion Apical Plasma Membrane Lamellipodium Filopodium T-tubule Midbody Cortical Actin Cytoskeleton Cleavage Furrow Cell Tip Extracellular Exosome Cell Periphery
	Molecular Function	Minor Groove Of Adenine-thymine-rich DNA Binding Protein Binding Zinc Ion Binding Histone Methyltransferase Activity (H3-K4 Specific) Identical Protein Binding Protein Homodimerization Activity Unmethylated CpG Binding Lysine-acetylated Histone Binding	RNA Binding Actin Binding Protein Binding Cadherin Binding Protein Kinase A Binding ATPase Binding
	Biological Process	Apoptotic Process Positive Regulation Of Transporter Activity Circadian Regulation Of Gene Expression Embryonic Hemopoiesis Histone H4-K16 Acetylation Histone H3-K4 Dimethylation Regulation Of Megakaryocyte Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Histone H3-K4 Methylation Positive Regulation Of Histone H3-K4 Methylation Protein-containing Complex Assembly Regulation Of Histone H3-K14 Acetylation Histone H3-K4 Trimethylation Histone H3-K4 Monomethylation Regulation Of Hematopoietic Stem Cell Differentiation Negative Regulation Of DNA Methylation Regulation Of Histone H3-K9 Acetylation	Regulation Of Cell Shape Regulation Of Cell Size Positive Regulation Of Gene Expression Protein Kinase A Signaling Positive Regulation Of Cell Migration Regulation Of Actin Filament Bundle Assembly Regulation Of Rap Protein Signal Transduction Negative Regulation Of Homotypic Cell-cell Adhesion Negative Regulation Of GTPase Activity Cellular Response To Platelet-derived Growth Factor Stimulus Regulation Of GTPase Activity Apical Protein Localization Establishment Of Protein Localization Negative Regulation Of Cell Size Barbed-end Actin Filament Capping Establishment Of Endothelial Barrier Protein Localization To Plasma Membrane Cellular Response To Thyroid Hormone Stimulus Regulation Of Ruffle Assembly Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Organelle Assembly Positive Regulation Of Protein Localization To Early Endosome Positive Regulation Of Cellular Protein Catabolic Process Negative Regulation Of Adherens Junction Organization Positive Regulation Of Early Endosome To Late Endosome Transport
Pathways		PKMTs methylate histone lysines RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs RUNX1 regulates transcription of genes involved in differentiation of HSCs Transcriptional regulation of granulopoiesis	Recycling pathway of L1 Recycling pathway of L1
Drugs			1D-myo-inositol 1,4,5-trisphosphate
Diseases		Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia)
GWAS		Apolipoprotein A1 levels ( 32203549) HDL cholesterol levels ( 32203549) Metabolic syndrome ( 31589552) Refractive error ( 32231278) Triglyceride levels ( 32203549)	Cognitive function ( 24684796) Coronary artery disease ( 32469254) Multiple sclerosis ( 31604244)
Interacting Genes		31 interacting genes: ASH2L AVP BMI1 CBX4 CREBBP CTNNB1 FASLG H3-3A H3-4 H3C1 H3C14 HCFC1 HCFC2 INS KAT8 MEN1 MTM1 OXT PAF1 PLXNB1 PPIE PPP1R15A RBBP5 RNF2 SBF1 SET SVIL TAF9 TASP1 TOP1 WDR5	20 interacting genes: ABCC2 ARHGDIA C1QTNF9 CALM1 CPNE1 CPNE2 CPNE4 DRD3 EZR GNA13 ICAM2 ITGB2 L1CAM LINC01554 PSME3 ROCK1 SLC9A3R1 SLC9A3R2 TSC1 VPS11
Entrez ID		4297	5962
HPRD ID		01162	01534
Ensembl ID		ENSG00000118058	ENSG00000137710
Uniprot IDs		Q03164	B0YJ88 P35241 Q6PKD3
PDB IDs		2AGH 2J2S 2JYI 2KKF 2KU7 2KYU 2LXS 2LXT 2MSR 2MTN 2W5Y 2W5Z 3EG6 3EMH 3LQH 3LQI 3LQJ 3P4F 3U85 3U88 4ESG 4GQ6 4NW3 5F5E 5F6L 5SVH 6EMQ 6KIU 6KIV 6KIX 6KIZ 6PWV 6PWW 6U9K 6U9M 6U9N 6U9R
Enriched GO Terms of Interacting Partners?
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