MARK3 and RECQL

Data Source:
BioGRID (proximity labelling technology)

		MARK3	RECQL
Description		microtubule affinity regulating kinase 3	RecQ like helicase
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Dendrite Extracellular Exosome	Nucleus Nucleoplasm Chromosome Cytoplasm Membrane
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Tau Protein Binding Tau-protein Kinase Activity Protein Serine Kinase Activity Protein Threonine Kinase Activity	DNA Binding DNA Helicase Activity Protein Binding ATP Binding Four-way Junction Helicase Activity Annealing Helicase Activity 3'-5' DNA Helicase Activity
	Biological Process	MAPK Cascade Microtubule Cytoskeleton Organization Protein Phosphorylation Peptidyl-serine Phosphorylation Positive Regulation Of Protein Binding Negative Regulation Of Hippo Signaling Intracellular Signal Transduction Peptidyl-serine Autophosphorylation	Double-strand Break Repair Via Homologous Recombination DNA Strand Renaturation DNA Unwinding Involved In DNA Replication DNA Repair DNA Recombination DNA Duplex Unwinding
Pathways		RAF activation MAP2K and MAPK activation Negative regulation of MAPK pathway Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants Signaling by RAF1 mutants
Drugs		Fostamatinib
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Blond vs. brown/black hair color ( 30531825) Body mass index ( 26426971) Brain morphology (MOSTest) ( 32665545) Coronary artery disease ( 29212778 33020668) Cutaneous melanoma or hair colour ( 32341527) Femoral neck bone mineral density ( 22504420) Granulocyte percentage of myeloid white cells ( 27863252) Heel bone mineral density ( 30598549 28869591) Height ( 31562340) Lymphocyte counts ( 32888494) Mean corpuscular hemoglobin ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 29403010 32888494 27863252) Monocyte percentage of white cells ( 32888494) Neutrophil percentage of white cells ( 32888494) Optic disc size ( 31809533) PR interval ( 32439900) Systolic blood pressure ( 30224653 30578418) Type 2 diabetes ( 30297969) White blood cell count ( 32888494)	Blood protein levels ( 30072576)
Interacting Genes		30 interacting genes: ANKRD7 ARHGEF2 ASB13 ATP6V0C CDC25C CHGB CLASP1 CLASP2 CPSF4 DYNLL1 FANCF FBXO7 HDAC7 KSR1 MAP2 MAPT MITF NOL11 PKP2 PMPCB PNPLA2 PRKCQ SAAL1 SFN TCEA2 TTR VPS11 YWHAG YWHAQ YWHAZ	4 interacting genes: KPNA2 KPNA4 RPA1 UBC
Entrez ID		4140	5965
HPRD ID		04058	02762
Ensembl ID		ENSG00000075413	ENSG00000004700
Uniprot IDs		P27448 Q86U11	A0A024RAV2 P46063
PDB IDs		2QNJ 3FE3	2V1X 2WWY 4U7D 6JTZ
Enriched GO Terms of Interacting Partners?
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