LTBP1 and ZFP36L2

Data Source:
BioGRID (affinity chromatography technology)

		LTBP1	ZFP36L2
Description		latent transforming growth factor beta binding protein 1	ZFP36 ring finger protein like 2
Image
GO Annotations	Cellular Component	Microfibril Extracellular Region Endoplasmic Reticulum Lumen Extracellular Matrix Protein-containing Complex Collagen-containing Extracellular Matrix	Nucleus Cytoplasm
	Molecular Function	Transforming Growth Factor Beta-activated Receptor Activity Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding Transforming Growth Factor Beta Binding Microfibril Binding	RNA Binding Protein Binding MRNA 3'-UTR AU-rich Region Binding Metal Ion Binding
	Biological Process	Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Sequestering Of TGFbeta In Extracellular Matrix Post-translational Protein Modification Cellular Protein Metabolic Process Regulation Of Transforming Growth Factor Beta Activation	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay MRNA Catabolic Process Response To Wounding Hemopoiesis T Cell Differentiation In Thymus Somatic Stem Cell Population Maintenance Regulation Of MRNA Stability Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of B Cell Differentiation Negative Regulation Of Fat Cell Differentiation Somatic Stem Cell Division Definitive Hemopoiesis 3'-UTR-mediated MRNA Destabilization ERK1 And ERK2 Cascade Cellular Response To Tumor Necrosis Factor Cellular Response To Epidermal Growth Factor Stimulus Cellular Response To Glucocorticoid Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Negative Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Stem Cell Differentiation
Pathways		Molecules associated with elastic fibres Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs
Diseases
GWAS		Carpal tunnel syndrome ( 30833571) Central corneal thickness ( 32528159 29760442) Diverticular disease ( 30177863) Height ( 28552196 20881960 25282103 25429064 19893584 23563607 31562340 20189936) Hip circumference adjusted for BMI ( 25673412) Immune reponse to smallpox (secreted IFN-alpha) ( 22610502) Immune response to smallpox vaccine (IL-6) ( 22610502) Intraocular pressure ( 29617998 29785010 29235454) Knee osteoarthritis ( 30374069) Male-pattern baldness ( 28196072) Optic disc size ( 31809533) Rosacea symptom severity ( 29771307) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412 28448500)	Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Crohn's disease ( 28067908) Diastolic blood pressure ( 27841878 31469255) Estimated glomerular filtration rate ( 31152163) Glucose homeostasis traits ( 25524916) Heel bone mineral density ( 30598549) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Inflammatory bowel disease ( 28067908) Lymphocyte counts ( 27863252) Lymphocyte percentage of white cells ( 27863252) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Neutrophil percentage of granulocytes ( 27863252) Neutrophil percentage of white cells ( 27863252) Offspring birth weight ( 31043758) Platelet count ( 27863252) Polycystic ovary syndrome ( 21151128) Red blood cell count ( 29403010 32888494) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Systolic blood pressure ( 27841878 28739976)
Interacting Genes		11 interacting genes: ATN1 CACNA1A FBN1 FBN2 FN1 HTRA1 IGFBP3 IGFBP5 ITGB5 TGFB1 TGM2	1 interacting genes: TRIM14
Entrez ID		4052	678
HPRD ID		01039	18319
Ensembl ID		ENSG00000049323	ENSG00000152518
Uniprot IDs		B7ZLY3 Q14766	P47974
PDB IDs		1KSQ	1RGO
Enriched GO Terms of Interacting Partners?
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