LTBP1 and FOXN2

Data Source:
BioGRID (affinity chromatography technology)

		LTBP1	FOXN2
Description		latent transforming growth factor beta binding protein 1	forkhead box N2
Image			No pdb structure
GO Annotations	Cellular Component	Microfibril Extracellular Region Endoplasmic Reticulum Lumen Extracellular Matrix Protein-containing Complex Collagen-containing Extracellular Matrix	Chromatin Nucleus Nucleoplasm Intracellular Membrane-bounded Organelle
	Molecular Function	Transforming Growth Factor Beta-activated Receptor Activity Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding Transforming Growth Factor Beta Binding Microfibril Binding	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Sequestering Of TGFbeta In Extracellular Matrix Post-translational Protein Modification Cellular Protein Metabolic Process Regulation Of Transforming Growth Factor Beta Activation	Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Skeletal Muscle Cell Differentiation
Pathways		Molecules associated with elastic fibres Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs
Diseases
GWAS		Carpal tunnel syndrome ( 30833571) Central corneal thickness ( 32528159 29760442) Diverticular disease ( 30177863) Height ( 28552196 20881960 25282103 25429064 19893584 23563607 31562340 20189936) Hip circumference adjusted for BMI ( 25673412) Immune reponse to smallpox (secreted IFN-alpha) ( 22610502) Immune response to smallpox vaccine (IL-6) ( 22610502) Intraocular pressure ( 29617998 29785010 29235454) Knee osteoarthritis ( 30374069) Male-pattern baldness ( 28196072) Optic disc size ( 31809533) Rosacea symptom severity ( 29771307) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412 28448500)	Bitter alcoholic beverage consumption ( 31046077) Chronotype ( 30696823) Glycated hemoglobin levels ( 28898252) HDL cholesterol levels ( 32203549) Itch intensity from mosquito bite ( 28199695) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Left-handedness ( 32989287) Macular thickness ( 30535121)
Interacting Genes		11 interacting genes: ATN1 CACNA1A FBN1 FBN2 FN1 HTRA1 IGFBP3 IGFBP5 ITGB5 TGFB1 TGM2	1 interacting genes: USP7
Entrez ID		4052	3344
HPRD ID		01039	00882
Ensembl ID		ENSG00000049323	ENSG00000170802
Uniprot IDs		B7ZLY3 Q14766	P32314
PDB IDs		1KSQ
Enriched GO Terms of Interacting Partners?
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