KLRC2 and FGF6

Data Source:
BioGRID (two hybrid)

		KLRC2	FGF6
Description		killer cell lectin like receptor C2	fibroblast growth factor 6
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Receptor Complex	Extracellular Region Extracellular Space Cytoplasm Sarcolemma
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding MHC Class I Protein Complex Binding Carbohydrate Binding Activating MHC Class Ib Receptor Activity Protein Antigen Binding	Fibroblast Growth Factor Receptor Binding Protein Binding Growth Factor Activity
	Biological Process	Stimulatory C-type Lectin Receptor Signaling Pathway Natural Killer Cell Mediated Immunity Cellular Defense Response Signal Transduction Positive Regulation Of Natural Killer Cell Degranulation Innate Immune Response Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity	MAPK Cascade Cartilage Condensation Angiogenesis Positive Regulation Of Protein Phosphorylation Positive Regulation Of Cell Population Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Animal Organ Morphogenesis Positive Regulation Of Gene Expression Cell Differentiation Regulation Of Cell Migration Myoblast Differentiation Positive Regulation Of Cell Division Positive Regulation Of Protein Kinase B Signaling
Pathways		DAP12 interactions DAP12 signaling DAP12 signaling	PI3K Cascade PIP3 activates AKT signaling Signaling by activated point mutants of FGFR1 FGFR4 ligand binding and activation FGFR1c ligand binding and activation FGFR2c ligand binding and activation Activated point mutants of FGFR2 Constitutive Signaling by Aberrant PI3K in Cancer Phospholipase C-mediated cascade: FGFR1 Phospholipase C-mediated cascade; FGFR2 Phospholipase C-mediated cascade; FGFR4 Downstream signaling of activated FGFR1 SHC-mediated cascade:FGFR1 PI-3K cascade:FGFR1 FRS-mediated FGFR1 signaling PI-3K cascade:FGFR2 SHC-mediated cascade:FGFR2 FRS-mediated FGFR2 signaling FRS-mediated FGFR4 signaling SHC-mediated cascade:FGFR4 PI-3K cascade:FGFR4 Negative regulation of FGFR1 signaling Negative regulation of FGFR2 signaling Negative regulation of FGFR4 signaling Signaling by FGFR2 in disease Signaling by FGFR1 in disease RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Drugs
Diseases
GWAS		Blood protein levels ( 28240269) Composite immunoglobulin trait (IgA/IgG) ( 28628107) Lymphocyte counts ( 32888494) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Neutrophil percentage of white cells ( 32888494 27863252) Plateletcrit ( 32888494) Red blood cell count ( 32888494)	Colorectal cancer ( 23263487) Medication use (antimigraine preparations) ( 31015401) Migraine ( 27182965 27322543) Migraine without aura ( 27322543) Phosphorus levels ( 29403010 20558539) Response to cytadine analogues (cytosine arabinoside) ( 24483146)
Interacting Genes		3 interacting genes: FBP1 HLA-E KLRD1	5 interacting genes: FGFR1 FGFR2 FGFR3 FGFR4 NCALD
Entrez ID		3822	2251
HPRD ID		04202	00623
Ensembl ID		ENSG00000205809	ENSG00000111241
Uniprot IDs		P26717	P10767
PDB IDs		2L35
Enriched GO Terms of Interacting Partners?
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