IL6R and SLC39A2

Data Source:
BioGRID (affinity chromatography technology)

		IL6R	SLC39A2
Description		interleukin 6 receptor	solute carrier family 39 member 2
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Interleukin-6 Receptor Complex External Side Of Plasma Membrane Apical Plasma Membrane Receptor Complex Ciliary Neurotrophic Factor Receptor Complex	Plasma Membrane Integral Component Of Plasma Membrane Membrane Cytoplasmic Vesicle Cytoplasmic Ribonucleoprotein Granule
	Molecular Function	Cytokine Receptor Activity Ciliary Neurotrophic Factor Receptor Activity Interleukin-6 Receptor Activity Interleukin-11 Receptor Activity Interleukin-6 Receptor Binding Protein Binding Enzyme Binding Cytokine Binding Interleukin-11 Binding Interleukin-6 Binding Protein Homodimerization Activity Ciliary Neurotrophic Factor Binding	Zinc Ion Transmembrane Transporter Activity Protein Binding
	Biological Process	Hepatic Immune Response Monocyte Chemotaxis Positive Regulation Of Leukocyte Chemotaxis Acute-phase Response Positive Regulation Of Cell Population Proliferation Positive Regulation Of Activation Of Janus Kinase Activity Vascular Endothelial Growth Factor Production Cytokine-mediated Signaling Pathway Endocrine Pancreas Development Positive Regulation Of Chemokine Production Positive Regulation Of Interleukin-6 Production Response To Cytokine Interleukin-11-mediated Signaling Pathway Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Defense Response To Gram-negative Bacterium Interleukin-6-mediated Signaling Pathway Ciliary Neurotrophic Factor-mediated Signaling Pathway Positive Regulation Of Glomerular Mesangial Cell Proliferation T-helper 17 Cell Lineage Commitment Extrinsic Apoptotic Signaling Pathway	Zinc Ion Transport Zinc Ion Transmembrane Transport
Pathways		Interleukin-6 signaling MAPK3 (ERK1) activation MAPK1 (ERK2) activation Interleukin-4 and Interleukin-13 signaling Transcriptional regulation of granulopoiesis Potential therapeutics for SARS	Zinc influx into cells by the SLC39 gene family
Drugs		Tocilizumab Sarilumab Satralizumab
Diseases
GWAS		Abdominal aortic aneurysm ( 27899403) Acute anterior uveitis (with or without ankylosing spondylitis) ( 25200001) Albumin-globulin ratio ( 29403010) Allergic disease (asthma, hay fever or eczema) ( 29083406) Ankylosing spondylitis ( 23749187) Asthma ( 32296059 21907864) Atopic dermatitis ( 26482879) Atrial fibrillation ( 29892015) Blood protein levels ( 30072576 29875488 28240269 23696881) Blood protein levels in cardiovascular risk ( 28369058) C-reactive protein ( 19567438 18439548) C-reactive protein levels ( 29403010 30388399 21300955) Cerebrospinal fluid levels of Alzheimer's disease-related proteins ( 25340798) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Coronary artery disease ( 32469254 29212778 26343387 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Fibrinogen ( 20031577 23969696) Fibrinogen levels ( 28107422 26561523) Interleukin-6 levels ( 32473944) Itch intensity from mosquito bite ( 28199695) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean platelet volume ( 32888494) Monocyte percentage of white cells ( 32888494 27863252) Mosquito bite size ( 28199695) Myocardial infarction ( 26343387) Parental longevity (combined parental attained age, Martingale residuals) ( 29227965) Platelet count ( 32888494) Protein quantitative trait loci ( 18464913) Pulmonary function ( 17903307) Red cell distribution width ( 32888494) Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy) ( 24554482) Rheumatoid arthritis ( 30423114 23143596 24390342) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Systemic lupus erythematosus ( 28714469)
Interacting Genes		11 interacting genes: ADRB2 CNTF ERAP1 IL6 IL6ST MAGI1 SGTB SRC STAT3 WWP1 WWP2	51 interacting genes: AQP1 AQP6 ARL13B BCL2L2 BTN2A2 C3orf52 C4orf3 CD79A CLCA4 CNR2 COL4A5 COMT CREB3L1 CXCR2 CYB561 EHHADH EMC6 FCER1G FXYD3 FXYD6 GJA8 GPR152 GPR42 KCNAB1 KCNAB2 LY6G6C MFSD6 MS4A13 PLN PNLIPRP1 SEC22A SLC18A1 SLC30A2 SLC30A8 SLC39A1 SLC39A9 SLC66A1 SLC7A1 SSMEM1 ST6GAL2 STATH TMEM107 TMEM14B TMEM229B TMEM237 TMEM54 TMEM60 TMEM86A TRHR UPK1B YIPF6
Entrez ID		3570	29986
HPRD ID		01000	15385
Ensembl ID		ENSG00000160712	ENSG00000165794
Uniprot IDs		A0A087WTB5 A0N0L5 P08887	Q9NP94
PDB IDs		1N26 1N2Q 1P9M 2ARW 5FUC
Enriched GO Terms of Interacting Partners?
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