ACADM and DBT

Data Source:
HPRD (in vivo, in vitro)

		ACADM	DBT
Description		acyl-CoA dehydrogenase medium chain	dihydrolipoamide branched chain transacylase E2
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GO Annotations	Cellular Component	Nucleus Mitochondrion Mitochondrial Matrix Axon Mitochondrial Membrane	Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol Mitochondrial Alpha-ketoglutarate Dehydrogenase Complex Microtubule Cytoskeleton Mitochondrial Nucleoid
	Molecular Function	Acyl-CoA Dehydrogenase Activity Identical Protein Binding Flavin Adenine Dinucleotide Binding Medium-chain-acyl-CoA Dehydrogenase Activity	Acetyltransferase Activity Lipoic Acid Binding Ubiquitin Protein Ligase Binding Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase Activity
	Biological Process	Fatty Acid Beta-oxidation Regulation Of Lipid Metabolic Process Carnitine Metabolic Process, CoA-linked Fatty Acid Beta-oxidation Using Acyl-CoA Dehydrogenase Carnitine Biosynthetic Process Medium-chain Fatty Acid Metabolic Process Medium-chain Fatty Acid Catabolic Process	Branched-chain Amino Acid Catabolic Process
Pathways		PPARA activates gene expression mitochondrial fatty acid beta-oxidation of unsaturated fatty acids Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA Beta oxidation of octanoyl-CoA to hexanoyl-CoA	Glyoxylate metabolism and glycine degradation Branched-chain amino acid catabolism
Drugs		Octanoyl-Coenzyme A Flavin adenine dinucleotide 3-thiaoctanoyl-CoA
Diseases		Disorders of fatty-acid oxidation, including: Medium-chain (MC) acyl-CoA dehydrogenase (AD) deficiency (MCADD); Short-chain AD deficiency (SCADD) ; Short-branched-chain AD deficiency (SBCADD) ; Very long-chain AD deficiency (VLCADD) ; Long-chain 3-hydroxyacyl CoA dehydrogenase deficiency (LCHADD) ; Trifunctional protein deficiency (TFP); Carnitine palmitoyltransferase deficiency (CPT); Carnitine-acylcarnitine translocase deficiency (CACT); Systemic primary carnitine deficiency (CDSP)	Maple syrup urine disease (MSUD)
GWAS		Acylcarnitine levels ( 26068415) Blood metabolite levels ( 24816252) Blood metabolite ratios ( 24816252) Daytime sleep phenotypes ( 27126917) Glycine levels ( 31070104 30837465) Metabolic traits ( 21886157) Metabolite levels ( 20037589) Serum metabolite concentrations in chronic kidney disease ( 29545352) Serum metabolite levels ( 23093944) Serum metabolite ratios in chronic kidney disease ( 29545352) Urinary metabolite levels in chronic kidney disease ( 31959995) Urinary metabolite modules (eigenmetabolites) in chronic kidney disease ( 31959995)	Lung cancer in ever smokers ( 28604730)
Interacting Genes		3 interacting genes: CALM1 CDC42 SUMO4
Entrez ID		34	1629
HPRD ID		08447	02010
Ensembl ID		ENSG00000117054	ENSG00000137992
Uniprot IDs		A0A0S2Z366 B4DJE7 B7Z9I1 P11310 Q5HYG7 Q5T4U5	P11182
PDB IDs		1EGC 1EGD 1EGE 1T9G 2A1T 4P13	1K8M 1K8O 1ZWV 2COO 3RNM
Enriched GO Terms of Interacting Partners?
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