BIRC5 and SSH2

Data Source:
BioGRID (affinity chromatography technology)

		BIRC5	SSH2
Description		baculoviral IAP repeat containing 5	slingshot protein phosphatase 2
Image
GO Annotations	Cellular Component	Nuclear Chromosome Chromosome, Centromeric Region Condensed Chromosome Kinetochore Nucleus Nucleoplasm Cytoplasm Cytosol Spindle Microtubule Midbody Chromosome Passenger Complex	Extracellular Space Cytoplasm Cytoskeleton
	Molecular Function	Protein Binding Microtubule Binding Enzyme Binding Small GTPase Binding Identical Protein Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Metal Ion Binding Chaperone Binding	Actin Binding Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Tyrosine/serine/threonine Phosphatase Activity Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity
	Biological Process	Protein Phosphorylation Apoptotic Process Chromosome Segregation Sensory Perception Of Sound Positive Regulation Of Cell Population Proliferation Cytokine-mediated Signaling Pathway Protein-containing Complex Localization Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Transcription, DNA-templated Cell Division Regulation Of Cell Cycle	Protein Dephosphorylation Actin Cytoskeleton Organization Negative Regulation Of Actin Filament Polymerization Peptidyl-tyrosine Dephosphorylation
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion SUMOylation of DNA replication proteins RHO GTPases Activate Formins Interleukin-4 and Interleukin-13 signaling TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain Mitotic Prometaphase Neddylation EML4 and NUDC in mitotic spindle formation
Drugs		Reserpine Berberine LY2181308
Diseases
GWAS		Blood trace element (Se levels) ( 23720494) Periodontitis (Mean PAL) ( 24024966)	Brain morphology (MOSTest) ( 32665545) Coffee consumption (cups per day) ( 25288136) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Heel bone mineral density ( 28869591) Hematocrit ( 32888494) Hemoglobin ( 32888494) Lung function (FEV1/FVC) ( 30804560) Lymphocyte counts ( 32888494 27863252) Monocyte count ( 32888494 27863252) Monocyte percentage of white cells ( 32888494) Neutrophil count ( 32888494) Peak expiratory flow ( 30804560) Red blood cell count ( 32888494) White blood cell count ( 32888494 27863252)
Interacting Genes		25 interacting genes: AURKA AURKB AURKC BIRC2 BIRC3 BIRC6 CASP3 CASP7 CASP9 CCDC85B CDCA8 CDK1 CDK4 DIABLO EVI5 FBXL7 H3-4 H3C14 HSP90AA1 INCENP KCNJ6 RAN RASA1 XIAP XPO1	2 interacting genes: ACTB CFL1
Entrez ID		332	85464
HPRD ID		04520	09487
Ensembl ID		ENSG00000089685	ENSG00000141298
Uniprot IDs		A0A0B4J1S3 H3BLT4 O15392	A0A3B3ITS1 B4DK64 F5H527 Q76I76
PDB IDs		1E31 1F3H 1XOX 2QFA 2RAW 2RAX 3UEC 3UED 3UEE 3UEF 3UEG 3UEH 3UEI 3UIG 3UIH 3UII 3UIJ 3UIK 4A0I 4A0J 4A0N 6SHO 6YIE 6YIF 6YIH	2NT2
Enriched GO Terms of Interacting Partners?
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