APAF1 and PAH

Data Source:
BioGRID (affinity chromatography technology)

		APAF1	PAH
Description		apoptotic peptidase activating factor 1	phenylalanine hydroxylase
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GO Annotations	Cellular Component	Extracellular Region Nucleus Cytosol Protein-containing Complex Secretory Granule Lumen Apoptosome Extracellular Exosome Ficolin-1-rich Granule Lumen	Cytosol
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Heat Shock Protein Binding Identical Protein Binding ADP Binding	Phenylalanine 4-monooxygenase Activity Iron Ion Binding
	Biological Process	Response To Hypoxia Kidney Development Neural Tube Closure Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Nervous System Development Aging Response To Nutrient Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Cardiac Muscle Cell Apoptotic Process Cell Differentiation Forebrain Development Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Neutrophil Degranulation Neuron Apoptotic Process Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Negative Regulation Of G0 To G1 Transition Cellular Response To Transforming Growth Factor Beta Stimulus Response To G1 DNA Damage Checkpoint Signaling Intrinsic Apoptotic Signaling Pathway Regulation Of Apoptotic DNA Fragmentation Positive Regulation Of Apoptotic Signaling Pathway	L-phenylalanine Catabolic Process Tyrosine Biosynthetic Process Cellular Amino Acid Biosynthetic Process Neurotransmitter Biosynthetic Process Catecholamine Biosynthetic Process
Pathways		Formation of apoptosome Activation of caspases through apoptosome-mediated cleavage SMAC (DIABLO) binds to IAPs SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes Neutrophil degranulation TP53 Regulates Transcription of Caspase Activators and Caspases Transcriptional Regulation by E2F6 Regulation of the apoptosome activity Regulation of the apoptosome activity	Phenylketonuria Phenylalanine metabolism
Drugs		ATP	Phenylalanine Sapropterin Norepinephrine Quinonoid 7,8-Tetrahydrobiopterin beta-2-Thienyl-L-alanine L-erythro-7,8-dihydrobiopterin D-norleucine Droxidopa
Diseases			Phenylketonuria (PKU); Hyperphenylalaninemia, BH4-deficient
GWAS			Amino acid levels ( 26068415) Bisphosphonate-associated atypical femoral fracture ( 31006051) Blood metabolite levels ( 24816252) Metabolite levels (small molecules and protein measures) ( 27005778) Plasma free amino acid levels ( 30659259) Plasma free amino acid levels (adjusted for one other PFAA) ( 30659259) Plasma free amino acid levels (adjusted for twenty other PFAAs) ( 30659259) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271)
Interacting Genes		18 interacting genes: APIP AVEN BCL2L1 BCL2L10 CASP3 CASP4 CASP8 CASP9 CYCS FAS FEM1B HIP1 HSP90AA1 HSPA1A NLRP1 PPP1CA TOP1 TRIAP1	3 interacting genes: PCBD1 QDPR RPS24
Entrez ID		317	5053
HPRD ID		03755	08943
Ensembl ID		ENSG00000120868	ENSG00000171759
Uniprot IDs		O14727	A0A024RBG4 P00439
PDB IDs		1C15 1CWW 1CY5 1Z6T 2P1H 2YGS 3J2T 3JBT 3YGS 4RHW 5JUY 5WVC 5WVE	1DMW 1J8T 1J8U 1KW0 1LRM 1MMK 1MMT 1PAH 1TDW 1TG2 2PAH 3PAH 4ANP 4PAH 5FII 5PAH 6HPO 6HYC 6N1K 6PAH
Enriched GO Terms of Interacting Partners?
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