NPBWR2 and RRM2

Data Source:
BioGRID (biochemical)

		NPBWR2	RRM2
Description		neuropeptides B and W receptor 2	ribonucleotide reductase regulatory subunit M2
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane Neuron Projection	Cytosol
	Molecular Function	G Protein-coupled Receptor Activity Opioid Receptor Activity Protein Binding Neuropeptide Receptor Activity Peptide Binding Neuropeptide Binding	Ribonucleoside-diphosphate Reductase Activity, Thioredoxin Disulfide As Acceptor Protein Binding Metal Ion Binding
	Biological Process	G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Opioid Receptor Signaling Pathway	Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle DNA Replication Deoxyribonucleotide Biosynthetic Process Nucleobase-containing Small Molecule Interconversion Negative Regulation Of G0 To G1 Transition
Pathways		Peptide ligand-binding receptors G alpha (i) signalling events	Interconversion of nucleotide di- and triphosphates G1/S-Specific Transcription Transcriptional Regulation by E2F6
Drugs			Cladribine Imexon Gallium nitrate Motexafin gadolinium GTI 2040
Diseases
GWAS		Body mass index ( 25673413) Cerebrospinal AB1-42 levels in normal cognition ( 29274321) Medication use (agents acting on the renin-angiotensin system) ( 31015401)	Kidney function decline traits ( 25493955) Prostate cancer ( 23535732)
Interacting Genes		18 interacting genes: BOLL CYSRT1 KPRP KRT31 KRT34 KRT40 KRTAP1-3 KRTAP10-3 KRTAP10-7 KRTAP10-9 KRTAP5-9 KRTAP6-2 NOTCH2NLA NPB NPW PHAF1 PNMA1 PSMA3	9 interacting genes: CDH1 CDK1 DNM1L KAT5 PLK3 RRM1 RRM2B SDCBP TP53
Entrez ID		2832	6241
HPRD ID		02841	01587
Ensembl ID		ENSG00000125522	ENSG00000171848
Uniprot IDs		P48146	P31350
PDB IDs			2UW2 3OLJ 3VPM 3VPN 3VPO
Enriched GO Terms of Interacting Partners?
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