GNG5 and MYH3

Data Source:
BioGRID (affinity chromatography technology)

		GNG5	MYH3
Description		G protein subunit gamma 5	myosin heavy chain 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Heterotrimeric G-protein Complex Plasma Membrane Membrane G-protein Beta/gamma-subunit Complex Extracellular Exosome	Cytosol Muscle Myosin Complex Sarcomere Myosin Filament Extracellular Exosome
	Molecular Function	GTPase Activity Protein Binding PDZ Domain Binding G-protein Beta-subunit Binding	Microfilament Motor Activity Calmodulin Binding ATP Binding ATPase Activity Myosin Phosphatase Activity Actin Filament Binding
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway	Skeletal Muscle Contraction Protein Dephosphorylation Muscle Organ Development Actin Filament-based Movement Muscle Filament Sliding Embryonic Limb Morphogenesis Sarcomere Organization ATP Metabolic Process Face Morphogenesis
Pathways		Activation of G protein gated Potassium channels Glucagon signaling in metabolic regulation G-protein activation Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Glucagon-like Peptide-1 (GLP1) regulates insulin secretion ADP signalling through P2Y purinoceptor 12 G beta:gamma signalling through PI3Kgamma Prostacyclin signalling through prostacyclin receptor Prostacyclin signalling through prostacyclin receptor Adrenaline,noradrenaline inhibits insulin secretion Adrenaline,noradrenaline inhibits insulin secretion Ca2+ pathway Ca2+ pathway G alpha (q) signalling events G alpha (12/13) signalling events G beta:gamma signalling through PLC beta G alpha (s) signalling events ADP signalling through P2Y purinoceptor 1 ADP signalling through P2Y purinoceptor 1 G alpha (i) signalling events G alpha (z) signalling events Glucagon-type ligand receptors Thromboxane signalling through TP receptor Vasopressin regulates renal water homeostasis via Aquaporins Thrombin signalling through proteinase activated receptors (PARs) Thrombin signalling through proteinase activated receptors (PARs) Presynaptic function of Kainate receptors Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding G beta:gamma signalling through BTK G beta:gamma signalling through CDC42 Extra-nuclear estrogen signaling ADORA2B mediated anti-inflammatory cytokines production Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	Striated Muscle Contraction
Drugs
Diseases			Distal arthrogryposis (DA)
GWAS			Post bronchodilator percent predicted FEV1 in smoking ( 30068317) Relative hand skill in reading disability ( 24068947)
Interacting Genes		12 interacting genes: AMOTL2 EPS15L1 GNB1 GNB2 GNB3 GNB4 GNB5 GOLGA2 KRT31 KRT40 MDFI TRAF1	9 interacting genes: APPL1 CLIP4 DYSF LAMTOR5 OPTN PPP1R7 PRKD3 SNAPIN TULP3
Entrez ID		2787	4621
HPRD ID		11865	01172
Ensembl ID		ENSG00000174021	ENSG00000109063
Uniprot IDs		P63218	P11055 Q5GJ67
PDB IDs
Enriched GO Terms of Interacting Partners?
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