GDF1 and NCAN

Data Source:
BioGRID (biochemical)

		GDF1	NCAN
Description		growth differentiation factor 1	neurocan
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Space	Extracellular Region Golgi Lumen Extracellular Matrix Lysosomal Lumen
	Molecular Function	Cytokine Activity Growth Factor Activity	Calcium Ion Binding Hyaluronic Acid Binding Carbohydrate Binding
	Biological Process	Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation BMP Signaling Pathway SMAD Protein Signal Transduction	Skeletal System Development Cell Adhesion Central Nervous System Development Extracellular Matrix Organization Chondroitin Sulfate Biosynthetic Process Chondroitin Sulfate Catabolic Process Dermatan Sulfate Biosynthetic Process
Pathways		Signaling by NODAL	A tetrasaccharide linker sequence is required for GAG synthesis Chondroitin sulfate biosynthesis Dermatan sulfate biosynthesis CS/DS degradation ECM proteoglycans Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Defective CHST14 causes EDS, musculocontractural type Defective CHSY1 causes TPBS L1CAM interactions NCAM1 interactions Defective B3GALT6 causes EDSP2 and SEMDJL1
Drugs			Beta-D-Glucose Thiodigalactoside Hyaluronic acid
Diseases		Conotruncal heart malformations, including: Double-outlet right ventricle; Persistent truncus arteriosus; Conotruncal anomaly face syndrome Tetralogy of Fallot
GWAS			Bipolar disorder ( 24618891 31043756 21353194) Bipolar I disorder ( 31043756) Bipolar II disorder ( 31043756) Brain morphology (MOSTest) ( 32665545) C-reactive protein levels or LDL-cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or total cholesterol levels (pleiotropy) ( 27286809) Cholesterol, total ( 19060911 26780889) LDL cholesterol ( 18193043 19060906 19060911 26780889) Nonalcoholic fatty liver disease ( 29385134) Plateletcrit ( 32888494) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656 23974872) Triglycerides ( 18193043 19060906 19060911)
Interacting Genes		1 interacting genes: HTR4	8 interacting genes: CNTN2 HMGB1 L1CAM NCAM1 PTN PTPRF TNC TNR
Entrez ID		2657	1463
HPRD ID		04194	02897
Ensembl ID		ENSG00000130283	ENSG00000130287
Uniprot IDs		A0A024R7N8 P27539	A0A024R7M3 O14594 Q4LE67
PDB IDs
Enriched GO Terms of Interacting Partners?
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