GCGR and BIRC5

Data Source:
BioGRID (affinity chromatography technology)

		GCGR	BIRC5
Description		glucagon receptor	baculoviral IAP repeat containing 5
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GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane	Nuclear Chromosome Chromosome, Centromeric Region Condensed Chromosome Kinetochore Nucleus Nucleoplasm Cytoplasm Cytosol Spindle Microtubule Midbody Chromosome Passenger Complex
	Molecular Function	Glucagon Receptor Activity Guanyl-nucleotide Exchange Factor Activity G Protein-coupled Peptide Receptor Activity Peptide Hormone Binding	Protein Binding Microtubule Binding Enzyme Binding Small GTPase Binding Identical Protein Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Metal Ion Binding Chaperone Binding
	Biological Process	Generation Of Precursor Metabolites And Energy Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Response To Nutrient Regulation Of Blood Pressure Cellular Response To Starvation Positive Regulation Of Gene Expression Glucose Homeostasis Response To Starvation Regulation Of Catalytic Activity Regulation Of Glycogen Metabolic Process Cellular Response To Glucagon Stimulus	Protein Phosphorylation Apoptotic Process Chromosome Segregation Sensory Perception Of Sound Positive Regulation Of Cell Population Proliferation Cytokine-mediated Signaling Pathway Protein-containing Complex Localization Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Transcription, DNA-templated Cell Division Regulation Of Cell Cycle
Pathways			Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion SUMOylation of DNA replication proteins RHO GTPases Activate Formins Interleukin-4 and Interleukin-13 signaling TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain Mitotic Prometaphase Neddylation EML4 and NUDC in mitotic spindle formation
Drugs		Glucagon	Reserpine Berberine LY2181308
Diseases
GWAS		Hematocrit ( 32888494)	Blood trace element (Se levels) ( 23720494) Periodontitis (Mean PAL) ( 24024966)
Interacting Genes		4 interacting genes: GCG GNAS TGM2 TP63	25 interacting genes: AURKA AURKB AURKC BIRC2 BIRC3 BIRC6 CASP3 CASP7 CASP9 CCDC85B CDCA8 CDK1 CDK4 DIABLO EVI5 FBXL7 H3-4 H3C14 HSP90AA1 INCENP KCNJ6 RAN RASA1 XIAP XPO1
Entrez ID		2642	332
HPRD ID		00678	04520
Ensembl ID		ENSG00000215644	ENSG00000089685
Uniprot IDs		P47871	A0A0B4J1S3 H3BLT4 O15392
PDB IDs		2A83 3CZF 4ERS 4L6R 4LF3 5EE7 5XEZ 6LMK 6LML 6WHC 6WPW	1E31 1F3H 1XOX 2QFA 2RAW 2RAX 3UEC 3UED 3UEE 3UEF 3UEG 3UEH 3UEI 3UIG 3UIH 3UII 3UIJ 3UIK 4A0I 4A0J 4A0N 6SHO 6YIE 6YIF 6YIH
Enriched GO Terms of Interacting Partners?
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