GIGYF2 and METTL21A

Data Source:
BioGRID (proximity labelling technology)

		GIGYF2	METTL21A
Description		GRB10 interacting GYF protein 2	methyltransferase like 21A
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GO Annotations	Cellular Component	Endosome Endoplasmic Reticulum Golgi Apparatus Cytosol Cytoplasmic Stress Granule Membrane Protein-containing Complex Perikaryon Proximal Dendrite	Nucleoplasm Cytoplasm Cytosol Protein-containing Complex
	Molecular Function	RNA Binding Protein Binding Cadherin Binding Proline-rich Region Binding	Protein Binding Protein Methyltransferase Activity Protein-lysine N-methyltransferase Activity Hsp70 Protein Binding Heat Shock Protein Binding ATPase Binding
	Biological Process	Posttranscriptional Gene Silencing Negative Regulation Of Translation Insulin-like Growth Factor Receptor Signaling Pathway MRNA Destabilization	Protein Methylation Peptidyl-lysine Methylation Regulation Of ATPase Activity
Pathways			Protein methylation
Drugs
Diseases		Parkinson's disease (PD)
GWAS		Anxiety and stress-related disorders ( 31116379) Autism spectrum disorder or schizophrenia ( 28540026) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Coronary artery disease ( 32469254 29212778 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Schizophrenia ( 25056061 29483656 23974872)	HDL cholesterol levels ( 32203549) Opioid sensitivity ( 23183491) Systolic blood pressure ( 28135244 28739976 30578418)
Interacting Genes		8 interacting genes: APC CNOT9 GRB10 GRB14 GRB7 RBM12 SNRPB WBP11	15 interacting genes: ARPC4 ATRIP HSPA1A HSPA5 HSPA8 LNX1 LZTS1 MEI4 MEOX2 MSRB3 PFDN5 ZBED8 ZNF620 ZNF655 ZRANB1
Entrez ID		26058	151194
HPRD ID		11639	14090
Ensembl ID		ENSG00000204120	ENSG00000144401
Uniprot IDs		Q6Y7W6	C9JES0 H7BXH9 Q8WXB1
PDB IDs		5NVL 5NVM	4LEC
Enriched GO Terms of Interacting Partners?
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