FOLR1 and INTS4

Data Source:
BioGRID (affinity chromatography technology)

		FOLR1	INTS4
Description		folate receptor alpha	integrator complex subunit 4
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Nucleus Endosome Endoplasmic Reticulum Membrane Plasma Membrane Cell Surface ER To Golgi Transport Vesicle Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Transport Vesicle Clathrin-coated Vesicle Anchored Component Of External Side Of Plasma Membrane Brush Border Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Extracellular Exosome	Nucleus Nucleoplasm Nucleolus Integrator Complex
	Molecular Function	Protein Binding Folic Acid Binding Signaling Receptor Activity Methotrexate Binding Folic Acid Receptor Activity	Protein Binding
	Biological Process	Heart Looping Neural Crest Cell Migration Involved In Heart Formation Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Receptor-mediated Endocytosis Cell Adhesion Fusion Of Sperm To Egg Plasma Membrane Involved In Single Fertilization Folic Acid Transport Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Axon Regeneration Sperm-egg Recognition Folic Acid Metabolic Process COPII Vesicle Coating Regulation Of Canonical Wnt Signaling Pathway Pharyngeal Arch Artery Morphogenesis Anterior Neural Tube Closure Cellular Response To Folic Acid Folate Import Across Plasma Membrane	SnRNA Processing SnRNA Transcription By RNA Polymerase II
Pathways		COPII-mediated vesicle transport Cargo concentration in the ER COPI-mediated anterograde transport	RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes
Drugs		Folic acid Vintafolide Farletuzumab
Diseases
GWAS			Mean reticulocyte volume ( 32888494) Platelet count ( 32888494) Tourette syndrome ( 30818990)
Interacting Genes		6 interacting genes: CUL3 IRAK3 LTB4R2 LYN NCAPH2 SLC35F6	7 interacting genes: HGS KIAA0513 LHX3 MEIS3 PYGM USHBP1 ZMIZ2
Entrez ID		2348	92105
HPRD ID		00638	12386
Ensembl ID		ENSG00000110195	ENSG00000149262
Uniprot IDs		A0A024R5H1 P15328	Q96HW7
PDB IDs		4KM6 4KM7 4KMX 4LRH 5IZQ
Enriched GO Terms of Interacting Partners?
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