SYNE1 and IYD

Data Source:
BioGRID (two hybrid)

		SYNE1	IYD
Description		spectrin repeat containing nuclear envelope protein 1	iodotyrosine deiodinase
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GO Annotations	Cellular Component	P-body Nucleus Nuclear Envelope Nuclear Outer Membrane Nucleoplasm Nucleolus Cytoplasm Golgi Apparatus Cytoskeleton Integral Component Of Membrane Sarcomere Nuclear Membrane Meiotic Nuclear Membrane Microtubule Tethering Complex Postsynaptic Membrane	Nucleoplasm Plasma Membrane Integral Component Of Plasma Membrane Cytoplasmic Vesicle Membrane
	Molecular Function	RNA Binding Actin Binding Protein Binding Lamin Binding Enzyme Binding Protein Homodimerization Activity Actin Filament Binding Cytoskeleton-nuclear Membrane Anchor Activity	Iodide Peroxidase Activity Protein Binding FMN Binding Oxidoreductase Activity
	Biological Process	Nucleus Organization Golgi Organization Spermatogenesis Muscle Cell Differentiation Nuclear Matrix Anchoring At Nuclear Membrane	Tyrosine Metabolic Process Thyroid Hormone Generation Thyroid Hormone Metabolic Process Cellular Oxidant Detoxification
Pathways		Meiotic synapsis	Thyroxine biosynthesis
Drugs			3,5-Diiodotyrosine
Diseases		Emery-Dreifuss muscular dystrophy Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)	Thyroid dyshormonogenesis; Dyshormogenetic goiter
GWAS		Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Bipolar disorder ( 28115744 21926972 31043756 28072414 20351715 21738484) Bipolar disorder or major depressive disorder ( 20351715) Bipolar I disorder ( 31043756) Body mass index ( 26426971) Endometriosis ( 28537267) Heel bone mineral density ( 30598549 28869591) Post bronchodilator FEV1 ( 26634245) Tonometry ( 17903302) Uterine fibroids ( 31249589 30194396 31649266)	Anger ( 24489884)
Interacting Genes		21 interacting genes: ACTC1 APC BDKRB2 CAPN1 CDC42 CDC5L CEP63 DISC1 DTNBP1 ECPAS EMD LINC00839 LMNA MTDH MUSK MYOM1 NDEL1 SH3BP5 TNIK TP53RK USP21	1 interacting genes: TRIM69
Entrez ID		23345	389434
HPRD ID		09762	16668
Ensembl ID		ENSG00000131018	ENSG00000009765
Uniprot IDs		A0A0C4DG40 B4E3R1 B7Z9Y6 F8WAI0 Q8NF91	Q2VPV9 Q6PHW0
PDB IDs		4DXR 6R15	4TTB 4TTC 5YAK
Enriched GO Terms of Interacting Partners?
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