JADE2 and KLK2

Data Source:
BioGRID (proximity labelling technology)

		JADE2	KLK2
Description		jade family PHD finger 2	kallikrein related peptidase 2
Image		No pdb structure
GO Annotations	Cellular Component	Histone Acetyltransferase Complex Nucleoplasm Extracellular Exosome	Extracellular Region Secretory Granule Extracellular Exosome
	Molecular Function	Protein Binding Transferase Activity Metal Ion Binding	Serine-type Endopeptidase Activity
	Biological Process	Protein Ubiquitination Histone H3 Acetylation Histone H4-K5 Acetylation Histone H4-K8 Acetylation Histone H4-K12 Acetylation Histone H4-K16 Acetylation	Regulation Of Systemic Arterial Blood Pressure Extracellular Matrix Disassembly Zymogen Activation
Pathways		HATs acetylate histones	Activation of Matrix Metalloproteinases Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Drugs
Diseases
GWAS		Adult body size ( 32376654) Age at first birth ( 27798627) Body mass index ( 28892062) Brain morphology (MOSTest) ( 32665545) Coffee consumption ( 31046077) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Hand grip strength ( 29691431) Household income (MTAG) ( 31844048) Mental health study participation (completed survey) ( 31263887) Monocyte percentage of white cells ( 32888494) Multiple sclerosis ( 31604244) Neutrophil count ( 32888494) Platelet distribution width ( 27863252) Subcortical volume (MOSTest) ( 32665545) Type 2 diabetes ( 28869590) White blood cell count ( 32888494)	Celiac disease ( 23936387) PCA3 expression level ( 23555189) Prostate cancer ( 31562322) Prostate-specific antigen levels ( 23359319 28139693) Prostate-specific antigen levels (conditioned on lead SNPs) ( 28139693) Tandem gait ( 26219847)
Interacting Genes		16 interacting genes: CBX8 CDCA7L CSNK2A1 FBXO7 GAS2L2 GORASP2 H3-4 ING4 ING5 MEAF6 PACSIN1 SASH1 ZBTB3 ZBTB5 ZNF417 ZNF496	14 interacting genes: A2M APP AR IGFBP2 POLR2A SEMG1 SEMG2 SERPINA3 SERPINA4 SERPINA5 SERPINB6 SERPINC1 SERPINE1 SERPINF2
Entrez ID		23338	3817
HPRD ID		15124	01006
Ensembl ID		ENSG00000043143	ENSG00000167751
Uniprot IDs		A0A0C4DFT8 B3KPL2 B4DFY8 G3XAA4 Q9NQC1	A0A024R4J4 A0A024R4N3 B4DU77 P20151
PDB IDs			4NFE 4NFF
Enriched GO Terms of Interacting Partners?
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