POFUT2 and BACE2

Data Source:
BioGRID (affinity chromatography technology)

		POFUT2	BACE2
Description		protein O-fucosyltransferase 2	beta-secretase 2
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GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Golgi Apparatus	Endosome Endoplasmic Reticulum Golgi Apparatus Trans-Golgi Network Plasma Membrane Membrane Integral Component Of Membrane Dense Core Granule
	Molecular Function	Peptide-O-fucosyltransferase Activity	Aspartic-type Endopeptidase Activity Protein Binding
	Biological Process	Mesoderm Formation Fucose Metabolic Process Regulation Of Gene Expression Regulation Of Epithelial To Mesenchymal Transition Protein O-linked Fucosylation Regulation Of Secretion Positive Regulation Of Protein Folding	Proteolysis Membrane Protein Ectodomain Proteolysis Peptide Hormone Processing Glucose Homeostasis Negative Regulation Of Amyloid Precursor Protein Biosynthetic Process Astrocyte Activation Amyloid-beta Metabolic Process
Pathways		O-glycosylation of TSR domain-containing proteins
Drugs
Diseases
GWAS		Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes ( 29221444) Logical memory (immediate recall) in mild cognitive impairment ( 29274321)	Adult body size ( 32376654) Body mass index ( 25673413) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Elevated fasting plasma glucose ( 30004843) Glycemic traits (pregnancy) ( 23903356)
Interacting Genes			3 interacting genes: APP GGA1 GGA2
Entrez ID		23275	25825
HPRD ID		09846	05744
Ensembl ID		ENSG00000186866	ENSG00000182240
Uniprot IDs		Q9Y2G5 S6FW71	Q9Y5Z0
PDB IDs		4AP5 4AP6	2EWY 3ZKG 3ZKI 3ZKM 3ZKN 3ZKQ 3ZKS 3ZKX 3ZL7 3ZLQ 4BEL 4BFB 6JSZ 6UJ0 6UJ1
Enriched GO Terms of Interacting Partners?
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