FSTL4 and JADE2

Data Source:
HPRD (in vitro)

		FSTL4	JADE2
Description		follistatin like 4	jade family PHD finger 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Secretory Granule	Histone Acetyltransferase Complex Nucleoplasm Extracellular Exosome
	Molecular Function	Calcium Ion Binding Brain-derived Neurotrophic Factor Binding	Protein Binding Transferase Activity Metal Ion Binding
	Biological Process	Multicellular Organism Development Cell Differentiation Negative Regulation Of Brain-derived Neurotrophic Factor Receptor Signaling Pathway Negative Regulation Of Collateral Sprouting Negative Regulation Of Dendritic Spine Development	Protein Ubiquitination Histone H3 Acetylation Histone H4-K5 Acetylation Histone H4-K8 Acetylation Histone H4-K12 Acetylation Histone H4-K16 Acetylation
Pathways			HATs acetylate histones
Drugs
Diseases
GWAS		Cognitive decline rate in late mild cognitive impairment ( 26252872) Eyebrow thickness ( 26926045) Gout ( 22179738) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Hypertension ( 22384028) Non-response to selective serotonin reuptake inhibitors and depression ( 27622933) Post bronchodilator FEV1 in COPD ( 26634245) Rheumatoid arthritis ( 30891314) Small cell lung carcinoma ( 28604730) Triglyceride levels ( 32154731 30698716) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716)	Adult body size ( 32376654) Age at first birth ( 27798627) Body mass index ( 28892062) Brain morphology (MOSTest) ( 32665545) Coffee consumption ( 31046077) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Hand grip strength ( 29691431) Household income (MTAG) ( 31844048) Mental health study participation (completed survey) ( 31263887) Monocyte percentage of white cells ( 32888494) Multiple sclerosis ( 31604244) Neutrophil count ( 32888494) Platelet distribution width ( 27863252) Subcortical volume (MOSTest) ( 32665545) Type 2 diabetes ( 28869590) White blood cell count ( 32888494)
Interacting Genes			16 interacting genes: CBX8 CDCA7L CSNK2A1 FBXO7 GAS2L2 GORASP2 H3-4 ING4 ING5 MEAF6 PACSIN1 SASH1 ZBTB3 ZBTB5 ZNF417 ZNF496
Entrez ID		23105	23338
HPRD ID		17022	15124
Ensembl ID		ENSG00000053108	ENSG00000043143
Uniprot IDs		Q6MZW2	A0A0C4DFT8 B3KPL2 B4DFY8 G3XAA4 Q9NQC1
PDB IDs
Enriched GO Terms of Interacting Partners?
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