RNF182 and SIRT5

Data Source:
HPRD (in vitro)

		RNF182	SIRT5
Description		ring finger protein 182	sirtuin 5
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Integral Component Of Membrane	Nucleus Mitochondrion Mitochondrial Intermembrane Space Mitochondrial Matrix Cytosol
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Metal Ion Binding	NAD+ ADP-ribosyltransferase Activity Zinc Ion Binding NAD-dependent Protein Deacetylase Activity Protein-malonyllysine Demalonylase Activity Protein-succinyllysine Desuccinylase Activity Protein-glutaryllysine Deglutarylase Activity NAD+ Binding
	Biological Process	Protein Ubiquitination	Protein ADP-ribosylation Protein Deacetylation Mitochondrion Organization Regulation Of Ketone Biosynthetic Process Protein Demalonylation Peptidyl-lysine Demalonylation Protein Desuccinylation Peptidyl-lysine Desuccinylation Protein Deglutarylation Peptidyl-lysine Deglutarylation Negative Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Transcriptional activation of mitochondrial biogenesis
Drugs			Adenosine-5-Diphosphoribose Nicotinamide 2'-O-Acetyl Adenosine-5-Diphosphoribose Suramin Cambinol
Diseases
GWAS		Lymphoma ( 23349640) Mean corpuscular hemoglobin concentration ( 27863252) Metabolite levels ( 23823483)	Perceived intensity of sweet substances ( 31005972)
Interacting Genes		5 interacting genes: UBC UBE2D1 UBE2K UBE2L3 UBE2N	1 interacting genes: APP
Entrez ID		221687	23408
HPRD ID		15264	06838
Ensembl ID		ENSG00000180537	ENSG00000124523
Uniprot IDs		A0A024QZW5 Q8N6D2	A0A024R012 Q9NXA8
PDB IDs			2B4Y 2NYR 3RIG 3RIY 4F4U 4F56 4G1C 4HDA 5BWL 5XHS 6ACE 6ACL 6ACO 6ACP 6EQS 6LJM 6LJN
Enriched GO Terms of Interacting Partners?
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