FAP and EPC2

Data Source:
HPRD (in vitro)

		FAP	EPC2
Description		fibroblast activation protein alpha	enhancer of polycomb homolog 2
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Cytoplasm Plasma Membrane Focal Adhesion Cell Surface Integral Component Of Membrane Lamellipodium Lamellipodium Membrane Ruffle Membrane Apical Part Of Cell Basal Part Of Cell Peptidase Complex	Piccolo NuA4 Histone Acetyltransferase Complex
	Molecular Function	Protease Binding Endopeptidase Activity Serine-type Endopeptidase Activity Integrin Binding Protein Binding Peptidase Activity Serine-type Peptidase Activity Dipeptidyl-peptidase Activity Identical Protein Binding Protein Homodimerization Activity	Histone Acetyltransferase Activity
	Biological Process	Angiogenesis Proteolysis Cell Adhesion Regulation Of Collagen Catabolic Process Negative Regulation Of Extracellular Matrix Disassembly Endothelial Cell Migration Proteolysis Involved In Cellular Protein Catabolic Process Regulation Of Fibrinolysis Negative Regulation Of Cell Proliferation Involved In Contact Inhibition Positive Regulation Of Cell Cycle Arrest Mitotic Cell Cycle Arrest Melanocyte Proliferation Positive Regulation Of Execution Phase Of Apoptosis Melanocyte Apoptotic Process Negative Regulation Of Extracellular Matrix Organization	DNA Repair Regulation Of Transcription By RNA Polymerase II Histone Acetylation
Pathways
Drugs		Sibrotuzumab
Diseases
GWAS		Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Coronary artery disease ( 33020668) Estimated glomerular filtration rate ( 30604766) Glomerular filtration rate ( 29403010) Inflammatory skin disease ( 25574825) Medication use (thyroid preparations) ( 31015401) Regular attendance at a pub or social club ( 29970889) Systemic lupus erythematosus ( 28714469)	Alzheimer's disease biomarkers ( 21123754) Chronotype ( 30696823) Metabolite levels ( 23823483) Protein quantitative trait loci ( 18464913) Pulse pressure ( 30578418) Relative amplitude of rest-activity cycles ( 30120083) Schizophrenia ( 29483656 30285260) Type 2 diabetes ( 32499647 30718926)
Interacting Genes		2 interacting genes: DPP4 PLAUR	2 interacting genes: EED EZH2
Entrez ID		2191	26122
HPRD ID		02674	13274
Ensembl ID		ENSG00000078098	ENSG00000135999
Uniprot IDs		B4DLR2 Q12884	Q52LR7
PDB IDs		1Z68
Enriched GO Terms of Interacting Partners?
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