F13A1 and DYNLL2

Data Source:
BioGRID (proximity labelling technology)

		F13A1	DYNLL2
Description		coagulation factor XIII A chain	dynein light chain LC8-type 2
Image
GO Annotations	Cellular Component	Extracellular Region Platelet Alpha Granule Lumen Collagen-containing Extracellular Matrix Blood Microparticle	Nucleus Centrosome Cytosol Cytoplasmic Dynein Complex Microtubule Plasma Membrane Cilium Postsynaptic Density Membrane Dynein Complex Myosin V Complex Ciliary Tip 9+0 Non-motile Cilium Postsynapse Glutamatergic Synapse
	Molecular Function	Protein-glutamine Gamma-glutamyltransferase Activity Protein Binding Metal Ion Binding	Motor Activity Protein Binding Identical Protein Binding Protein-containing Complex Binding Dynein Intermediate Chain Binding Dynein Light Intermediate Chain Binding Scaffold Protein Binding
	Biological Process	Platelet Degranulation Blood Coagulation Peptide Cross-linking Protein Phosphopantetheinylation Cytokine-mediated Signaling Pathway Blood Coagulation, Fibrin Clot Formation	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Macroautophagy Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Intraciliary Transport Involved In Cilium Assembly Cilium Assembly Positive Regulation Of ATP-dependent Microtubule Motor Activity, Plus-end-directed
Pathways		Platelet degranulation Common Pathway of Fibrin Clot Formation Interleukin-4 and Interleukin-13 signaling	Activation of BMF and translocation to mitochondria Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Macroautophagy MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion HSP90 chaperone cycle for steroid hormone receptors (SHR) Intraflagellar transport RHO GTPases Activate Formins COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase HCMV Early Events Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation
Drugs		N-Acetyl-Serine Thrombin Prothrombin Human thrombin Anti-inhibitor coagulant complex
Diseases		Factor XIII deficiency
GWAS		Age-related cognitive decline (memory) (slope of z-scores) ( 30954325) End-stage coagulation ( 23381943) Entorhinal cortical volume ( 21116278) GIP levels in response to oral glucose tolerance test (120 minutes) ( 29093273) Interleukin-10 levels ( 22205395) Night sleep phenotypes ( 27126917) Response to lamotrigine and valproic acid in genetic generalized epilepsy ( 32308125) Type 2 diabetes (age of onset) ( 28060188) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Blood protein levels ( 30072576)
Interacting Genes		13 interacting genes: ANXA7 CDKN1A F13B F2 FGA FGG FN1 NUDT21 PTK2 SERPINF2 SH3GL2 TK1 UFD1	35 interacting genes: BCL2L11 BMF C12orf40 C14orf119 DLGAP1 DNAL4 DPPA3 DYNC1I1 EWSR1 FAM117B GABARAPL2 GPHN GPRIN2 HDAC6 HMBOX1 HOMER3 IHO1 KANK2 MEOX2 MORN3 MYO5A OTUD6A PAK1 PKIA PKIG RASGRP3 SECISBP2L SKAP1 SMCP SPAG8 THAP10 TLK1 TPPP XIAP ZAR1
Entrez ID		2162	140735
HPRD ID		00604	06489
Ensembl ID		ENSG00000124491	ENSG00000264364
Uniprot IDs		P00488	Q96FJ2
PDB IDs		1EVU 1EX0 1F13 1FIE 1GGT 1GGU 1GGY 1QRK 4KTY 5MHL 5MHM 5MHN 5MHO	2XQQ 3P8M 4D07
Enriched GO Terms of Interacting Partners?
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