ETFDH and CLCN3

Data Source:
BioGRID (affinity chromatography technology)

		ETFDH	CLCN3
Description		electron transfer flavoprotein dehydrogenase	chloride voltage-gated channel 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Mitochondrial Matrix Integral Component Of Mitochondrial Inner Membrane Mitochondrial Membrane	Golgi Membrane Lysosomal Membrane Early Endosome Late Endosome Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Synaptic Vesicle External Side Of Plasma Membrane Cell Surface Endosome Membrane Vesicle Membrane Membrane Integral Component Of Membrane Secretory Granule Cytoplasmic Vesicle Early Endosome Membrane Late Endosome Membrane Ruffle Membrane Specific Granule Intracellular Membrane-bounded Organelle Axon Terminus Phagocytic Vesicle Recycling Endosome Glutamatergic Synapse
	Molecular Function	Electron-transferring-flavoprotein Dehydrogenase Activity Protein Binding Electron Transfer Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Metal Ions, Flavin As Acceptor Metal Ion Binding Quinone Binding Ubiquinone Binding Flavin Adenine Dinucleotide Binding 4 Iron, 4 Sulfur Cluster Binding	Voltage-gated Chloride Channel Activity Chloride Channel Activity Protein Binding ATP Binding Antiporter Activity Solute:proton Antiporter Activity PDZ Domain Binding Volume-sensitive Chloride Channel Activity
	Biological Process	Response To Oxidative Stress Electron Transport Chain Respiratory Electron Transport Chain Fatty Acid Beta-oxidation Using Acyl-CoA Dehydrogenase	Regulation Of PH Phagocytosis, Engulfment Adult Locomotory Behavior Synaptic Transmission, Glutamatergic Photoreceptor Cell Maintenance Negative Regulation Of Cell Volume Endosomal Lumen Acidification Synaptic Transmission, GABAergic Synaptic Vesicle Lumen Acidification Chloride Transmembrane Transport Positive Regulation Of Reactive Oxygen Species Biosynthetic Process
Pathways		Respiratory electron transport	Stimuli-sensing channels
Drugs		Metformin 2-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-Triol
Diseases		Glutaric acidemia; Glutaric acidemia, type I (GA1); Glutaric acidemia, type II (GA2); Multiple acyl coenzyme A dehydrogenase deficiency
GWAS		Acylcarnitine levels ( 26068415) Blood metabolite levels ( 24816252) Blood metabolite ratios ( 24816252) Blood protein levels ( 28240269) Metabolic traits ( 21886157) Metabolite levels ( 31628463 20037589) Serum metabolite levels ( 23093944)	Autism spectrum disorder or schizophrenia ( 28540026) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Schizophrenia ( 28991256 25056061 29483656 30285260)
Interacting Genes		8 interacting genes: GSC2 HSD17B10 KRTAP11-1 KRTAP13-2 MYH7B OTX1 TRIM69 ZNF581	6 interacting genes: CFTR DNAJC5 GOPC HSPB1 PDZK1 SLC9A3R1
Entrez ID		2110	1182
HPRD ID		01978	02785
Ensembl ID		ENSG00000171503	ENSG00000109572
Uniprot IDs		B4DEQ0 Q16134	B3KXK0 P51790
PDB IDs
Enriched GO Terms of Interacting Partners?
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