DPAGT1 and ETS1

Data Source:
BioGRID (biochemical)

		DPAGT1	ETS1
Description		dolichyl-phosphate N-acetylglucosaminephosphotransferase 1	ETS proto-oncogene 1, transcription factor
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GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane Integral Component Of Endoplasmic Reticulum Membrane Intracellular Membrane-bounded Organelle	Chromatin Nucleus Nucleoplasm Cytoplasm
	Molecular Function	UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase Activity UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase Activity Protein Binding Phospho-N-acetylmuramoyl-pentapeptide-transferase Activity Transferase Activity, Transferring Glycosyl Groups Identical Protein Binding Metal Ion Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Transcription Factor Binding Histone Acetyltransferase Binding Identical Protein Binding
	Biological Process	UDP-N-acetylglucosamine Metabolic Process Protein N-linked Glycosylation Dolichol-linked Oligosaccharide Biosynthetic Process Dolichyl Diphosphate Biosynthetic Process Dolichol Metabolic Process	Response To Hypoxia Regulation Of Transcription By RNA Polymerase II Immune Response Female Pregnancy Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Response To Mechanical Stimulus Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Gene Expression Regulation Of Extracellular Matrix Disassembly Hypothalamus Development Pituitary Gland Development Cell Differentiation PML Body Organization Response To Estradiol Response To Laminar Fluid Shear Stress Positive Regulation Of Blood Vessel Endothelial Cell Migration Estrous Cycle Positive Regulation Of Erythrocyte Differentiation Regulation Of Angiogenesis Positive Regulation Of Angiogenesis Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Cell Motility Positive Regulation Of Inflammatory Response Positive Regulation Of Cellular Component Movement Angiogenesis Involved In Wound Healing Cellular Response To Hydrogen Peroxide Response To Interleukin-1 Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell
Pathways		Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2	Oncogene Induced Senescence
Drugs
Diseases		Congenital disorders of glycosylation (CDG) type I
GWAS		Estimated glomerular filtration rate ( 31152163) Lymphocyte percentage of white cells ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494)	Adverse response to drug ( 30420678) Albumin-globulin ratio ( 29403010) Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma ( 30929738 32296059) Asthma (childhood onset) ( 30929738) Atopic dermatitis ( 26482879) Celiac disease ( 22057235 20190752 25920553 30572963) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Depressive and manic episodes in bipolar disorder ( 26297903) Depressive episodes in bipolar disorder ( 26297903) Eczema ( 31361310) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Follicular lymphoma ( 25279986) Glaucoma ( 31959993 30054594) Glaucoma (multi-trait analysis) ( 31959993) Granulocyte count ( 27863252) Height ( 31562340) Inflammatory bowel disease ( 28067908) Intraocular pressure ( 29617998 29785010 31959993 30054594) Itch intensity from mosquito bite ( 28199695) Liver fibrosis in pediatric non-alcoholic fatty acid liver disease ( 28918882) Lung function (FVC) ( 30061609) Lymphocyte counts ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494 27863252) Manganese levels ( 26025379) Medication use (thyroid preparations) ( 31015401) Monocyte count ( 32888494 27863252) Mosquito bite size ( 28199695) Multiple sclerosis ( 31604244 24076602) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494 27863252) Neutrophil percentage of white cells ( 32888494) Non-albumin protein levels ( 29403010) Obesity-related traits ( 23251661) Platelet count ( 32888494 27863252) Plateletcrit ( 32888494 27863252) Psoriasis ( 25903422 23143594) Psoriasis vulgaris ( 26626624) Refractive error ( 32231278) Rheumatoid arthritis ( 30423114 22446963 24390342) Rheumatoid arthritis (ACPA-positive) ( 24532676) Self-reported allergy ( 23817569) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Systemic lupus erythematosus ( 27399966 23273568 26663301 26502338 20169177 28714469 19838193) Type 2 diabetes ( 30054458 30297969 30718926) Ulcerative colitis ( 28067908) White blood cell count ( 32888494 27863252)
Interacting Genes		2 interacting genes: LSM8 MFSD3	50 interacting genes: APLP2 APP ARID4B ARL6IP4 ATF2 BRCA1 CAMK2A CAMK2B COP1 CREBBP CYBC1 DAXX DNMT3L EIF5B EP300 ETS2 FOS GATA3 HTATIP2 JUN MAF MAPK1 MAPK3 MAPK7 MED23 MEIS1 NCL NCOR1 NFKB1 NR3C1 PARP1 PAX5 POU1F1 RBBP6 RPL13A RUNX1T1 RUNX2 SMAD3 SP1 SP100 SPI1 SRA1 SRC SRSF11 STAT5B STAT6 TBP TDP2 UBE2I XRCC6
Entrez ID		1798	2113
HPRD ID		01879	01260
Ensembl ID		ENSG00000172269	ENSG00000134954
Uniprot IDs		A0A024R3H8 Q9H3H5	A8K725 B4DW78 P14921
PDB IDs		5LEV 5O5E 6BW5 6BW6 6FM9 6FWZ 6JQ3	1GVJ 2NNY 2STT 2STW 3MFK 3RI4 3WTS 3WTT 3WTU 3WTV 3WTW 3WTX 3WTY 3WTZ 3WU0 3WU1 4L0Y 4L0Z 4L18 4LG0 5ZMC
Enriched GO Terms of Interacting Partners?
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