CYP51A1 and STT3B

Data Source:
BioGRID (proximity labelling technology)

		CYP51A1	STT3B
Description		cytochrome P450 family 51 subfamily A member 1	STT3 oligosaccharyltransferase complex catalytic subunit B
Image
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane	Endoplasmic Reticulum Oligosaccharyltransferase Complex Membrane Integral Component Of Membrane Protein-containing Complex Oligosaccharyltransferase I Complex
	Molecular Function	Monooxygenase Activity Iron Ion Binding Sterol 14-demethylase Activity Oxidoreductase Activity Heme Binding	Dolichyl-diphosphooligosaccharide-protein Glycotransferase Activity Protein Binding Metal Ion Binding
	Biological Process	Steroid Biosynthetic Process Cholesterol Biosynthetic Process Sterol Metabolic Process Negative Regulation Of Protein Catabolic Process Regulation Of Cholesterol Biosynthetic Process Negative Regulation Of Protein Secretion Demethylation Negative Regulation Of Amyloid-beta Clearance	Protein N-linked Glycosylation Glycoprotein Catabolic Process Response To Unfolded Protein Protein N-linked Glycosylation Via Asparagine Ubiquitin-dependent ERAD Pathway Co-translational Protein Modification Post-translational Protein Modification
Pathways		Cholesterol biosynthesis Endogenous sterols Activation of gene expression by SREBF (SREBP) EGR2 and SOX10-mediated initiation of Schwann cell myelination
Drugs		Tioconazole Itraconazole Levoketoconazole (S)-econazole
Diseases
GWAS		Hippocampal volume in Alzheimer's disease dementia ( 29274321) Lifespan ( 25918517) Pulse pressure ( 30578418)	3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Periodontal disease-related phenotype (Socransky) ( 24347629) Urate levels ( 31578528)
Interacting Genes		1 interacting genes: ZNF420	1 interacting genes: INCA1
Entrez ID		1595	201595
HPRD ID		03381	12268
Ensembl ID		ENSG00000001630	ENSG00000163527
Uniprot IDs		A0A0C4DFL7 Q16850	Q8TCJ2
PDB IDs		3JUS 3JUV 3LD6 4UHI 4UHL 6Q2T 6UEZ	6S7T
Enriched GO Terms of Interacting Partners?
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