ADRB3 and IDO1

Data Source:
HPRD (in vitro)

		ADRB3	IDO1
Description		adrenoceptor beta 3	indoleamine 2,3-dioxygenase 1
Image
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Receptor Complex	Cytoplasm Cytosol Smooth Muscle Contractile Fiber Stereocilium Bundle
	Molecular Function	G Protein-coupled Receptor Activity Beta-adrenergic Receptor Activity Protein Binding Beta3-adrenergic Receptor Activity Protein Homodimerization Activity Epinephrine Binding Norepinephrine Binding	Tryptophan 2,3-dioxygenase Activity Electron Transfer Activity Heme Binding Indoleamine 2,3-dioxygenase Activity Metal Ion Binding
	Biological Process	Norepinephrine-epinephrine-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure Desensitization Of G Protein-coupled Receptor Signaling Pathway By Arrestin Carbohydrate Metabolic Process Generation Of Precursor Metabolites And Energy Energy Reserve Metabolic Process Receptor-mediated Endocytosis G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Positive Regulation Of MAPK Cascade Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Positive Regulation Of Cold-induced Thermogenesis	Immune System Process Positive Regulation Of T Cell Tolerance Induction Positive Regulation Of Chronic Inflammatory Response Positive Regulation Of Type 2 Immune Response Tryptophan Catabolic Process Inflammatory Response Female Pregnancy Tryptophan Catabolic Process To Kynurenine Electron Transport Chain Response To Lipopolysaccharide Negative Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-12 Production Multicellular Organismal Response To Stress Kynurenic Acid Biosynthetic Process 'de Novo' NAD Biosynthetic Process From Tryptophan Swimming Behavior Negative Regulation Of T Cell Proliferation Regulation Of Activated T Cell Proliferation Negative Regulation Of T Cell Apoptotic Process Positive Regulation Of T Cell Apoptotic Process
Pathways		Adrenoceptors G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production	Tryptophan catabolism
Drugs		Amphetamine Bethanidine Olanzapine Norepinephrine Nortriptyline Propranolol Paroxetine Trimipramine Cryptenamine Alprenolol Terbutaline Salmeterol Pindolol Formoterol Salbutamol Ergoloid mesylate Isoprenaline Arbutamine Amiodarone Fenoterol Ephedra sinica root Mephentermine Clenbuterol Oxprenolol Celiprolol Nebivolol Amibegron Solabegron Droxidopa Bufuralol Bopindolol Bupranolol Mirabegron Racepinephrine Dihydroergocornine DL-Methylephedrine Dihydroergocristine Vibegron	Nitric Oxide Cannabidiol Medical Cannabis Nabiximols
Diseases
GWAS			Blood metabolite levels ( 24816252) Blood protein levels ( 29875488)
Interacting Genes		3 interacting genes: ADRB2 GNAS SRC	5 interacting genes: APP DDX24 FBXL17 PPP1R16A TERF2IP
Entrez ID		155	3620
HPRD ID		00188	00935
Ensembl ID		ENSG00000188778	ENSG00000131203
Uniprot IDs		A8KAG8 P13945	A0A348GSI3 P14902
PDB IDs		2CDW	2D0T 2D0U 4PK5 4PK6 4U72 4U74 5EK2 5EK3 5EK4 5ETW 5WHR 5WMU 5WMV 5WMW 5WMX 5WN8 5XE1 6AZU 6AZV 6AZW 6CXU 6CXV 6DPQ 6DPR 6E35 6E40 6E41 6E42 6E43 6E44 6E45 6E46 6F0A 6KOF 6KPS 6KW7 6MQ6 6O3I 6PU7 6PZ1 6R63 6TUE 6V52 6WJY
Enriched GO Terms of Interacting Partners?
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