NDUFAF6 and TMEM67

Data Source:
BioGRID (unspecified method)

		NDUFAF6	TMEM67
Description		NADH:ubiquinone oxidoreductase complex assembly factor 6	transmembrane protein 67
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Mitochondrion Mitochondrial Inner Membrane	Endoplasmic Reticulum Membrane Centrosome Integral Component Of Membrane Cytoplasmic Vesicle Membrane Ciliary Transition Zone MKS Complex Ciliary Membrane
	Molecular Function		Protein Binding Filamin Binding Unfolded Protein Binding
	Biological Process	Mitochondrial Respiratory Chain Complex I Assembly	Negative Regulation Of Centrosome Duplication Ubiquitin-dependent ERAD Pathway Cilium Assembly Ciliary Basal Body-plasma Membrane Docking
Pathways		Complex I biogenesis	Anchoring of the basal body to the plasma membrane
Drugs
Diseases		Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (MT-C1D); Complex II deficiency (MT-C2D); Complex III deficiency (MT-C3D); Complex IV deficiency (MT-C4D); Complex V deficiency (MT-ATPSD); Leigh syndrome (LS); Kearns-Sayre Syndrome (KSS); LCHD deficiency (LCHD); Leber Hereditary Optic Neuropathy (LHON); Myoclonic Epilepsy and Ragged-Red Fiber Disease (MERRF); NARP; MELAS; ACAD9 deficiency; HADH deficiency; HIBCH deficiency; GRACILE syndrome	Joubert syndrome COACH syndrome Nephronophthisis-medullary cystic kidney disease, including; Nephronophthisis (NPH) ; Nephronophthisis-like nephropathy 1; Medullary cystic kidney disease 1; Medullary cystic kidney disease 2 (MSKD2) Meckel syndrome (MKS); Meckel-Gruber syndrome
GWAS		Alcohol dependence symptom count ( 29460428) Alzheimer's disease ( 31473137) Alzheimer's disease (late onset) ( 24162737 30820047) Apolipoprotein A1 levels ( 32203549) Central corneal thickness ( 32528159 29760442) Fasting plasma glucose ( 31932636) HDL cholesterol levels ( 32203549) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) Intraocular pressure ( 29617998) Macular thickness ( 30535121) Platelet distribution width ( 32888494) Pulse pressure ( 30224653 30578418) Red blood cell count ( 32888494) Serum uric acid levels ( 30993211 29403010) Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia ( 25710658)
Interacting Genes		2 interacting genes: GUCD1 OTX1	2 interacting genes: MKS1 UBQLN1
Entrez ID		137682	91147
HPRD ID		17553	11324
Ensembl ID		ENSG00000156170	ENSG00000164953
Uniprot IDs		A0A075B6P0 Q330K2	Q5HYA8
PDB IDs
Enriched GO Terms of Interacting Partners?
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