MROH2B and RICTOR

Data Source:
BioGRID (affinity chromatography technology)

		MROH2B	RICTOR
Description		maestro heat like repeat family member 2B	RPTOR independent companion of MTOR complex 2
Image		No pdb structure
GO Annotations	Cellular Component	Acrosomal Vesicle Cytoplasm Sperm Flagellum Sperm Midpiece	Cytosol TORC2 Complex
	Molecular Function		Protein Binding Protein Kinase Binding Ribosome Binding Protein Serine/threonine Kinase Activator Activity
	Biological Process	Spermatogenesis Protein Kinase A Signaling Cell Differentiation	Positive Regulation Of Endothelial Cell Proliferation Embryo Development Ending In Birth Or Egg Hatching Regulation Of Gene Expression Viral Process Peptidyl-serine Phosphorylation Positive Regulation Of Actin Filament Polymerization Actin Cytoskeleton Reorganization Positive Regulation Of TOR Signaling Activation Of Protein Kinase B Activity Regulation Of Actin Cytoskeleton Organization Regulation Of Peptidyl-serine Phosphorylation TORC2 Signaling Regulation Of GTPase Activity Regulation Of Inflammatory Response Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Protein Kinase B Signaling Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Establishment Of Cell Polarity
Pathways			PIP3 activates AKT signaling CD28 dependent PI3K/Akt signaling VEGFR2 mediated vascular permeability Constitutive Signaling by AKT1 E17K in Cancer Regulation of TP53 Degradation
Drugs
Diseases
GWAS			Daytime sleep phenotypes ( 27126917) Immature fraction of reticulocytes ( 32888494) Obesity-related traits ( 23251661) Post bronchodilator FEV1 ( 26634245) Red blood cell count ( 32888494)
Interacting Genes			11 interacting genes: CHUK CUL1 EIF4EBP1 GSK3A GSK3B IKBKB ILK MTOR PLK1 SGK1 SIRT1
Entrez ID		133558	253260
HPRD ID		08808	10682
Ensembl ID		ENSG00000171495	ENSG00000164327
Uniprot IDs		B3KXY2 Q4G0Z6 Q7Z745	Q6R327
PDB IDs			5ZCS
Enriched GO Terms of Interacting Partners?
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