VSIG4 and POLE

Data Source:
BioGRID (biochemical)

		VSIG4	POLE
Description		V-set and immunoglobulin domain containing 4	DNA polymerase epsilon, catalytic subunit
Image
GO Annotations	Cellular Component	Integral Component Of Membrane Protein-containing Complex	Nucleus Nucleoplasm Plasma Membrane Epsilon DNA Polymerase Complex
	Molecular Function	Complement Component C3b Binding Protein Binding	Nucleotide Binding DNA Binding Chromatin Binding DNA-directed DNA Polymerase Activity Protein Binding Zinc Ion Binding Single-stranded DNA 3'-5' Exodeoxyribonuclease Activity 4 Iron, 4 Sulfur Cluster Binding
	Biological Process	Complement Activation, Alternative Pathway Negative Regulation Of Interleukin-2 Production Negative Regulation Of T Cell Proliferation Negative Regulation Of Macrophage Activation Negative Regulation Of Complement Activation, Alternative Pathway	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle DNA Synthesis Involved In DNA Repair DNA Replication DNA Replication Initiation Leading Strand Elongation Base-excision Repair, Gap-filling Nucleotide-excision Repair, DNA Gap Filling Telomere Maintenance Via Semi-conservative Replication DNA Replication Proofreading Embryonic Organ Development Nucleic Acid Phosphodiester Bond Hydrolysis
Pathways			Recognition of DNA damage by PCNA-containing replication complex PCNA-Dependent Long Patch Base Excision Repair Termination of translesion DNA synthesis HDR through Homologous Recombination (HRR) Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER DNA replication initiation Activation of the pre-replicative complex
Drugs			Cladribine
Diseases
GWAS		Male-pattern baldness ( 28196072) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494)	Body mass index ( 26426971) Metabolite levels ( 23823483) Urate levels in overweight individuals ( 25811787)
Interacting Genes		7 interacting genes: APP C3 FATE1 JAGN1 PDK2 TRIM72 VAMP5	12 interacting genes: ABHD16A GINS4 MDM2 PCNA POLA1 POLD4 POLE2 POLE4 RAD17 STK19 TOPBP1 XRCC5
Entrez ID		11326	5426
HPRD ID		02286	07177
Ensembl ID		ENSG00000155659	ENSG00000177084
Uniprot IDs		Q9Y279	Q07864
PDB IDs		2ICC 2ICE 2ICF 5IMK 5IML	5VBN
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?