VPS45 and SV2A

Data Source:
BioGRID (affinity chromatography technology)

		VPS45	SV2A
Description		vacuolar protein sorting 45 homolog	synaptic vesicle glycoprotein 2A
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Cellular_component Golgi Apparatus Endosome Membrane Integral Component Of Membrane	Endoplasmic Reticulum Plasma Membrane Cell-cell Junction Synaptic Vesicle Integral Component Of Membrane Integral Component Of Synaptic Vesicle Membrane Dendrite Synaptic Vesicle Membrane Neuromuscular Junction Neuron Projection Neuronal Cell Body Presynaptic Active Zone Glutamatergic Synapse GABA-ergic Synapse
	Molecular Function	Molecular_function Protein Binding	Protein Kinase Binding Transmembrane Transporter Activity
	Biological Process	Intracellular Protein Transport Vesicle Docking Involved In Exocytosis Blood Coagulation Vesicle-mediated Transport	Cellular Calcium Ion Homeostasis Regulation Of Gamma-aminobutyric Acid Secretion Synaptic Vesicle Priming Transmembrane Transport
Pathways		Intra-Golgi traffic Factors involved in megakaryocyte development and platelet production	Toxicity of botulinum toxin type D (botD) Toxicity of botulinum toxin type A (botA) Toxicity of botulinum toxin type F (botF) Toxicity of botulinum toxin type E (botE)
Drugs			Levetiracetam Brivaracetam Seletracetam
Diseases
GWAS		anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Bipolar disorder ( 31043756) Broad depression or schizophrenia ( 30626913) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Obesity in adult survivors of childhood cancer not exposed to cranial radiation ( 25963547) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656) Uric acid levels ( 21294900)	Anthropometric traits ( 30166351) Anthropometric traits (multi-trait analysis) ( 30166351) Height ( 25429064 31562340 18391951) Lung function (FEV1) ( 26635082)
Interacting Genes		11 interacting genes: BCAR3 CASP8 IGF1R PAX2 PTPN1 RB1CC1 RBSN SNTG1 STX16 VPS11 VPS18	4 interacting genes: ATXN1 DNAJC5 LAMA5 LTB4R2
Entrez ID		11311	9900
HPRD ID		10301	08922
Ensembl ID		ENSG00000136631	ENSG00000159164
Uniprot IDs		A0A2R8YE10 B7Z360 B7Z5D4 Q9NRW7	B4E000 Q7L0J3
PDB IDs			4V11
Enriched GO Terms of Interacting Partners?
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