CHI3L1 and TSPAN15

Data Source:
BioGRID (genetic interference, affinity chromatography technology)

		CHI3L1	TSPAN15
Description		chitinase 3 like 1	tetraspanin 15
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Endoplasmic Reticulum Extracellular Matrix Specific Granule Lumen Perinuclear Region Of Cytoplasm Extracellular Exosome	Endoplasmic Reticulum Lumen Cytosol Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Nuclear Body Cell Junction Late Endosome Membrane Intracellular Membrane-bounded Organelle Tetraspanin-enriched Microdomain
	Molecular Function	Chitinase Activity Extracellular Matrix Structural Constituent Protein Binding Chitin Binding Carbohydrate Binding	Protein Binding Enzyme Binding
	Biological Process	Carbohydrate Metabolic Process Chitin Catabolic Process Apoptotic Process Inflammatory Response Activation Of NF-kappaB-inducing Kinase Activity Response To Mechanical Stimulus Positive Regulation Of Peptidyl-threonine Phosphorylation Lung Development Interleukin-8 Production Response To Tumor Necrosis Factor Neutrophil Degranulation Positive Regulation Of Angiogenesis Cartilage Development Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of ERK1 And ERK2 Cascade Response To Interleukin-1 Response To Interleukin-6 Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor	Regulation Of Notch Signaling Pathway Cellular Protein Metabolic Process Negative Regulation Of Notch Signaling Pathway Protein Maturation Protein Localization To Plasma Membrane
Pathways		Neutrophil degranulation	Amyloid fiber formation
Drugs
Diseases
GWAS		Asthma ( 31959851) Blood protein levels ( 29875488) Blood protein levels in cardiovascular risk ( 28369058) Clozapine-induced agranulocytosis ( 25187353) Metabolite levels ( 23823483) YKL-40 levels ( 18403759)	Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Height ( 31562340) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Response to taxane treatment (placlitaxel) ( 23006423) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Thrombosis ( 26908601) Type 2 diabetes ( 32499647) Venous thromboembolism ( 25772935 28373160 31420334 31676865)
Interacting Genes			5 interacting genes: BTRC GYPC RGS2 STRIT1 SYNE4
Entrez ID		1116	23555
HPRD ID		03314	15511
Ensembl ID		ENSG00000133048	ENSG00000099282
Uniprot IDs		A0A024R969 P36222	O95858
PDB IDs		1HJV 1HJW 1HJX 1LA7 1NWR 1NWS 1NWT 1NWU
Enriched GO Terms of Interacting Partners?
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