ADCY2 and AHRR

Data Source:
HPRD (in vitro)

		ADCY2	AHRR
Description		adenylate cyclase 2	aryl-hydrocarbon receptor repressor
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Membrane Dendrite Membrane Raft	Chromatin Nucleus Nucleoplasm Cytosol Aryl Hydrocarbon Receptor Complex
	Molecular Function	Magnesium Ion Binding Adenylate Cyclase Activity ATP Binding Adenylate Cyclase Binding Manganese Ion Binding	Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Nuclear Receptor Activity Protein Binding Protein Dimerization Activity
	Biological Process	Renal Water Homeostasis CAMP Biosynthetic Process G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway CAMP-mediated Signaling Activation Of Protein Kinase A Activity Cellular Response To Glucagon Stimulus Cellular Response To Forskolin	Regulation Of Transcription By RNA Polymerase II Xenobiotic Metabolic Process Intracellular Receptor Signaling Pathway
Pathways		Glucagon signaling in metabolic regulation PKA activation PKA activation in glucagon signalling Adenylate cyclase activating pathway Adenylate cyclase inhibitory pathway Adenylate cyclase inhibitory pathway G alpha (s) signalling events G alpha (s) signalling events G alpha (i) signalling events G alpha (z) signalling events G alpha (z) signalling events Vasopressin regulates renal water homeostasis via Aquaporins Hedgehog 'off' state ADORA2B mediated anti-inflammatory cytokines production ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis	PPARA activates gene expression Phase I - Functionalization of compounds Endogenous sterols Xenobiotics Aryl hydrocarbon receptor signalling
Drugs		Colforsin 2',5'-DIDEOXY-ADENOSINE 3'-MONOPHOSPHATE Aurothioglucose
Diseases
GWAS		Anxiety and stress-related disorders ( 31116379) Atorvastatin-induced myopathy ( 31220337) Bipolar disorder ( 24618891 31043756) Bipolar disorder (age of onset <21) or attention deficit hyperactivity disorder ( 27890468) Bipolar disorder or attention deficit hyperactivity disorder ( 27890468) Bipolar I disorder ( 31043756) Capecitabine sensitivity ( 22864933) Coffee consumption ( 31046077) Cognitive decline rate in late mild cognitive impairment ( 26252872) Food addiction ( 27106561) Mean arterial pressure (alcohol consumption interaction) ( 24376456) Oropharynx cancer ( 27749845) Pars opercularis volume ( 31530798) Plasma factor VII activating protease levels ( 30070759) Posterior-cingulate cortex volume ( 31530798) Smoking status (heavy vs never) ( 26423011) Visceral fat ( 22589738)	Breast cancer ( 29059683) Cystic fibrosis severity ( 21602797) Estimated glomerular filtration rate ( 31015462) Fat distribution (HIV) ( 21897333) Hemoglobin levels ( 32327693) Intraocular pressure ( 29617998) Systolic blood pressure ( 30224653)
Interacting Genes		6 interacting genes: ADCY1 ADCY5 DRD4 F2RL1 GNAS GNG2	1 interacting genes: ARNT
Entrez ID		108	57491
HPRD ID		00052	07356
Ensembl ID		ENSG00000078295	ENSG00000063438
Uniprot IDs		Q08462 Q71UM8	A9YTQ3
PDB IDs			5Y7Y
Enriched GO Terms of Interacting Partners?
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