ADCY2 and GCDH

Data Source:
BioGRID (two hybrid)

		ADCY2	GCDH
Description		adenylate cyclase 2	glutaryl-CoA dehydrogenase
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Membrane Dendrite Membrane Raft	Mitochondrion Mitochondrial Matrix
	Molecular Function	Magnesium Ion Binding Adenylate Cyclase Activity ATP Binding Adenylate Cyclase Binding Manganese Ion Binding	Fatty-acyl-CoA Binding Glutaryl-CoA Dehydrogenase Activity Flavin Adenine Dinucleotide Binding
	Biological Process	Renal Water Homeostasis CAMP Biosynthetic Process G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway CAMP-mediated Signaling Activation Of Protein Kinase A Activity Cellular Response To Glucagon Stimulus Cellular Response To Forskolin	Lysine Catabolic Process Tryptophan Metabolic Process Fatty Acid Beta-oxidation Using Acyl-CoA Dehydrogenase Fatty-acyl-CoA Biosynthetic Process
Pathways		Glucagon signaling in metabolic regulation PKA activation PKA activation in glucagon signalling Adenylate cyclase activating pathway Adenylate cyclase inhibitory pathway Adenylate cyclase inhibitory pathway G alpha (s) signalling events G alpha (s) signalling events G alpha (i) signalling events G alpha (z) signalling events G alpha (z) signalling events Vasopressin regulates renal water homeostasis via Aquaporins Hedgehog 'off' state ADORA2B mediated anti-inflammatory cytokines production ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis	Lysine catabolism
Drugs		Colforsin 2',5'-DIDEOXY-ADENOSINE 3'-MONOPHOSPHATE Aurothioglucose	Flavin adenine dinucleotide S-4-Nitrobutyryl-CoA
Diseases			Glutaric acidemia; Glutaric acidemia, type I (GA1); Glutaric acidemia, type II (GA2); Multiple acyl coenzyme A dehydrogenase deficiency
GWAS		Anxiety and stress-related disorders ( 31116379) Atorvastatin-induced myopathy ( 31220337) Bipolar disorder ( 24618891 31043756) Bipolar disorder (age of onset <21) or attention deficit hyperactivity disorder ( 27890468) Bipolar disorder or attention deficit hyperactivity disorder ( 27890468) Bipolar I disorder ( 31043756) Capecitabine sensitivity ( 22864933) Coffee consumption ( 31046077) Cognitive decline rate in late mild cognitive impairment ( 26252872) Food addiction ( 27106561) Mean arterial pressure (alcohol consumption interaction) ( 24376456) Oropharynx cancer ( 27749845) Pars opercularis volume ( 31530798) Plasma factor VII activating protease levels ( 30070759) Posterior-cingulate cortex volume ( 31530798) Smoking status (heavy vs never) ( 26423011) Visceral fat ( 22589738)	Blood metabolite levels ( 24816252) Clozapine-induced agranulocytosis ( 25187353) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Mean corpuscular hemoglobin ( 32888494 27863252 19862010) Mean corpuscular hemoglobin concentration ( 32888494 27863252) Mean corpuscular volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red blood cell count ( 32888494 27863252) Red cell distribution width ( 32888494) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252)
Interacting Genes		6 interacting genes: ADCY1 ADCY5 DRD4 F2RL1 GNAS GNG2	10 interacting genes: A2M APOE CDC37 ECSIT EXOC6 MAST1 NOS3 PSEN1 PSEN2 RNF32
Entrez ID		108	2639
HPRD ID		00052	01977
Ensembl ID		ENSG00000078295	ENSG00000105607
Uniprot IDs		Q08462 Q71UM8	A0A024R7F9 Q92947
PDB IDs			1SIQ 1SIR 2R0M 2R0N
Enriched GO Terms of Interacting Partners?
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