ADCY2 and CDH18

Data Source:
BioGRID (two hybrid)

		ADCY2	CDH18
Description		adenylate cyclase 2	cadherin 18
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Membrane Dendrite Membrane Raft	Plasma Membrane Adherens Junction Integral Component Of Membrane Catenin Complex
	Molecular Function	Magnesium Ion Binding Adenylate Cyclase Activity ATP Binding Adenylate Cyclase Binding Manganese Ion Binding	Calcium Ion Binding Cadherin Binding
	Biological Process	Renal Water Homeostasis CAMP Biosynthetic Process G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway CAMP-mediated Signaling Activation Of Protein Kinase A Activity Cellular Response To Glucagon Stimulus Cellular Response To Forskolin	Cell Morphogenesis Cell-cell Junction Assembly Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Multicellular Organism Development Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Adherens Junction Organization Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules
Pathways		Glucagon signaling in metabolic regulation PKA activation PKA activation in glucagon signalling Adenylate cyclase activating pathway Adenylate cyclase inhibitory pathway Adenylate cyclase inhibitory pathway G alpha (s) signalling events G alpha (s) signalling events G alpha (i) signalling events G alpha (z) signalling events G alpha (z) signalling events Vasopressin regulates renal water homeostasis via Aquaporins Hedgehog 'off' state ADORA2B mediated anti-inflammatory cytokines production ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis	Adherens junctions interactions
Drugs		Colforsin 2',5'-DIDEOXY-ADENOSINE 3'-MONOPHOSPHATE Aurothioglucose
Diseases
GWAS		Anxiety and stress-related disorders ( 31116379) Atorvastatin-induced myopathy ( 31220337) Bipolar disorder ( 24618891 31043756) Bipolar disorder (age of onset <21) or attention deficit hyperactivity disorder ( 27890468) Bipolar disorder or attention deficit hyperactivity disorder ( 27890468) Bipolar I disorder ( 31043756) Capecitabine sensitivity ( 22864933) Coffee consumption ( 31046077) Cognitive decline rate in late mild cognitive impairment ( 26252872) Food addiction ( 27106561) Mean arterial pressure (alcohol consumption interaction) ( 24376456) Oropharynx cancer ( 27749845) Pars opercularis volume ( 31530798) Plasma factor VII activating protease levels ( 30070759) Posterior-cingulate cortex volume ( 31530798) Smoking status (heavy vs never) ( 26423011) Visceral fat ( 22589738)	Childhood body mass index ( 33045005) Depression (quantitative trait) ( 20800221) Diabetes (gestational) ( 31269844) Erectile dysfunction ( 30583798) Metabolic coherence (transcriptomic) ( 30852652) Mitochondrial DNA levels ( 25240745) Obesity in adult survivors of childhood cancer exposed to cranial radiation ( 25963547) Obstetric antiphospholipid syndrome ( 28424481) Resistant hypertension ( 31545351) Response to anti-TNF therapy in rheumatoid arthritis ( 26776603) Serum metabolite concentrations in chronic kidney disease ( 29545352) Type 2 diabetes ( 31049640)
Interacting Genes		6 interacting genes: ADCY1 ADCY5 DRD4 F2RL1 GNAS GNG2	4 interacting genes: CDH12 CDH6 CDH9 MYOG
Entrez ID		108	1016
HPRD ID		00052	04314
Ensembl ID		ENSG00000078295	ENSG00000145526
Uniprot IDs		Q08462 Q71UM8	D6RER2 Q13634
PDB IDs
Enriched GO Terms of Interacting Partners?
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