P3H3 and OS9

Data Source:
BioGRID (affinity chromatography technology)

		P3H3	OS9
Description		prolyl 3-hydroxylase 3	OS9 endoplasmic reticulum lectin
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Catalytic Complex	Hrd1p Ubiquitin Ligase Complex Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Endoplasmic Reticulum Quality Control Compartment
	Molecular Function	Iron Ion Binding Procollagen-proline 3-dioxygenase Activity L-ascorbic Acid Binding	Protease Binding Protein Binding Carbohydrate Binding
	Biological Process	Negative Regulation Of Cell Population Proliferation Peptidyl-lysine Hydroxylation Peptidyl-proline Hydroxylation Collagen Metabolic Process Collagen Biosynthetic Process	Ubiquitin-dependent Protein Catabolic Process Protein Targeting Protein Retention In ER Lumen Protein Ubiquitination Ubiquitin-dependent ERAD Pathway Retrograde Protein Transport, ER To Cytosol Response To Endoplasmic Reticulum Stress Transmembrane Transport Negative Regulation Of Retrograde Protein Transport, ER To Cytosol Endoplasmic Reticulum Mannose Trimming
Pathways		Collagen biosynthesis and modifying enzymes	ABC-family proteins mediated transport Hedgehog ligand biogenesis Hh mutants are degraded by ERAD Defective CFTR causes cystic fibrosis ER Quality Control Compartment (ERQC)
Drugs		Ascorbic acid Proline
Diseases
GWAS			Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (MOSTest) ( 32665545) Multiple sclerosis ( 31604244) Rheumatoid arthritis (ACPA-positive) ( 24532676)
Interacting Genes		6 interacting genes: KRT31 KRTAP1-3 KRTAP12-3 KRTAP9-2 TRIM55 TRIM63	19 interacting genes: ACVR1B CPNE6 CREB3 DCSTAMP DYSF EGLN1 EGLN3 EIF6 FOXM1 HIF1A HSP90B1 LINC00839 MEP1B RBX1 SMAD2 SNRPD2 SREBF2 TRPV4 ZNF512B
Entrez ID		10536	10956
HPRD ID		10039	17804
Ensembl ID		ENSG00000110811	ENSG00000135506
Uniprot IDs		Q8IVL6	Q13438
PDB IDs			3AIH
Enriched GO Terms of Interacting Partners?
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