HYOU1 and IL1RL1

Data Source:
BioGRID (enzymatic study)

		HYOU1	IL1RL1
Description		hypoxia up-regulated 1	interleukin 1 receptor like 1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Endoplasmic Reticulum Endoplasmic Reticulum Lumen Smooth Endoplasmic Reticulum Focal Adhesion Membrane Endoplasmic Reticulum Chaperone Complex Extracellular Exosome Endocytic Vesicle Lumen	Extracellular Region Cytosol Plasma Membrane Focal Adhesion External Side Of Plasma Membrane Integral Component Of Membrane
	Molecular Function	Adenyl-nucleotide Exchange Factor Activity Protein Binding ATP Binding Unfolded Protein Binding Chaperone Binding	Interleukin-33 Binding Interleukin-33 Receptor Activity Cytokine Receptor Activity Interleukin-1 Receptor Activity Protein Binding NAD(P)+ Nucleosidase Activity NAD+ Nucleotidase, Cyclic ADP-ribose Generating
	Biological Process	Response To Ischemia Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Receptor-mediated Endocytosis Response To Endoplasmic Reticulum Stress IRE1-mediated Unfolded Protein Response Regulation Of Catalytic Activity Cellular Response To Hypoxia Negative Regulation Of Hypoxia-induced Intrinsic Apoptotic Signaling Pathway	Negative Regulation Of T-helper 1 Type Immune Response Immune Response Signal Transduction Negative Regulation Of Interferon-gamma Production Positive Regulation Of Chemokine Production Positive Regulation Of Interleukin-5 Production Interleukin-33-mediated Signaling Pathway Positive Regulation Of Macrophage Activation Positive Regulation Of Inflammatory Response
Pathways		Scavenging by Class F Receptors Scavenging by Class F Receptors XBP1(S) activates chaperone genes	PIP3 activates AKT signaling PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Interleukin-33 signaling
Drugs
Diseases
GWAS		Post bronchodilator FEV1/FVC ratio ( 26634245)	Adult asthma ( 30578877) Allergic disease (asthma, hay fever or eczema) ( 29785011) Allergic rhinitis ( 30013184 31361310) Allergic sensitization ( 30013184 23817571) Allergy ( 27182965) Asthma ( 23028483 21804549 31361310 31959851 30929738 27182965 32296059 31619474 26620591 29273806) Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 31036433 30929738 29273806) Asthma (moderate or severe) ( 30552067) Asthma (time to onset) ( 27130862) Asthma and hay fever ( 24388013) Asthma onset (childhood vs adult) ( 30929738) Asthma or allergic disease (pleiotropy) ( 29785011) Atopic dermatitis ( 23042114 26482879) Blood protein levels ( 30072576 29875488 28240269) Blood protein levels in cardiovascular risk ( 28369058) Celiac disease ( 20190752 18311140) Crohn's disease ( 28067908 21102463) Delirium ( 29631748) Eosinophil counts ( 29403010 19198610 32888494) Eosinophil percentage of white cells ( 32888494) FEV1 ( 30804560) Inflammatory bowel disease ( 28067908 23128233) Lung function (FEV1/FVC) ( 30804560) Nasal polyps ( 30643255) Neutrophil percentage of white cells ( 32888494) Primary biliary cholangitis ( 26394269) Self-reported allergy ( 23817569) Serum protein levels (sST2) ( 23999434) Waist circumference ( 23966867)
Interacting Genes		3 interacting genes: CDC42 LINC01554 SEL1L	18 interacting genes: APP ASGR2 CLEC12B CLEC2D CLEC7A CREB3L1 GPR152 GPR42 HRAS IL33 MCFD2 MYD88 SIGLEC12 SLC38A1 TIRAP TMED1 TSPAN18 YIPF6
Entrez ID		10525	9173
HPRD ID		03448	03123
Ensembl ID		ENSG00000149428	ENSG00000115602
Uniprot IDs		A0A384P5T6 A0A494C039 B3KXH0 B7Z602 B7Z766 Q6IN67 Q9Y4L1	Q01638
PDB IDs			4KC3
Enriched GO Terms of Interacting Partners?
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