IRAG1 and ASXL1

Data Source:
BioGRID (affinity chromatography technology)

		IRAG1	ASXL1
Description		inositol 1,4,5-triphosphate receptor associated 1	ASXL transcriptional regulator 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Integral Component Of Membrane Sarcoplasmic Reticulum Platelet Dense Tubular Network Membrane Perinuclear Region Of Cytoplasm	Nucleoplasm PR-DUB Complex
	Molecular Function	Protein Binding	DNA Binding Chromatin Binding Transcription Coactivator Activity Protein Binding Retinoic Acid Receptor Binding Peroxisome Proliferator Activated Receptor Binding Metal Ion Binding
	Biological Process	CGMP-mediated Signaling	Cell Morphogenesis Heart Morphogenesis Transcription, DNA-templated Animal Organ Morphogenesis Negative Regulation Of Lipid Storage Protein Deubiquitination Hemopoiesis Response To Retinoic Acid Negative Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Monoubiquitinated Histone H2A Deubiquitination Regulation Of Kidney Size Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Retinoic Acid Receptor Signaling Pathway Thymus Development Bone Marrow Development Homeostasis Of Number Of Cells Lung Saccule Development Glomerular Visceral Epithelial Cell Development
Pathways		cGMP effects	UCH proteinases
Drugs
Diseases			C syndrome, including: Opitz trigonocephaly syndrome; Bohring-Opitz syndrome (BOPS)
GWAS			Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Inflammatory bowel disease ( 28067908) Red cell distribution width ( 32888494)
Interacting Genes		2 interacting genes: ITPR1 PRKG1	6 interacting genes: APP GOLGA6L9 H1-2 SRPK1 STAT3 UBC
Entrez ID		10335	171023
HPRD ID		05242	16516
Ensembl ID		ENSG00000072952	ENSG00000171456
Uniprot IDs		Q9Y6F6	Q498B9 Q8IXJ9
PDB IDs
Enriched GO Terms of Interacting Partners?
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