RNF41 and GDF11

Data Source:
BioGRID (proximity labelling technology)

		RNF41	GDF11
Description		ring finger protein 41	growth differentiation factor 11
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GO Annotations	Cellular Component	Cytosol Perinuclear Region Of Cytoplasm Endoplasmic Reticulum Tubular Network	Extracellular Space Nucleoplasm Protein-containing Complex Intracellular Membrane-bounded Organelle
	Molecular Function	Ubiquitin-protein Transferase Activity Erythropoietin Receptor Binding Interleukin-3 Receptor Binding Protein Binding Zinc Ion Binding Protein Domain Specific Binding Receptor Tyrosine Kinase Binding Small GTPase Binding Identical Protein Binding Ubiquitin Protein Ligase Activity	Cytokine Activity Protein Binding Growth Factor Activity
	Biological Process	Protein Polyubiquitination Autophagy Negative Regulation Of Cell Population Proliferation Proteasomal Protein Catabolic Process Protein Ubiquitination Negative Regulation Of Cell Migration Regulation Of MAPK Cascade Regulation Of Lymphocyte Differentiation Regulation Of Myeloid Cell Differentiation Positive Regulation Of Protein Catabolic Process Positive Regulation Of DNA-binding Transcription Factor Activity Protein Autoubiquitination Regulation Of Protein Kinase B Signaling Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Mitophagy Regulation Of Establishment Of Cell Polarity Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process	Skeletal System Development Metanephros Development Ureteric Bud Development Nervous System Development Mesoderm Development Negative Regulation Of Cell Population Proliferation Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Spinal Cord Anterior/posterior Patterning Pancreas Development Negative Regulation Of Neuron Differentiation Cell Maturation Camera-type Eye Morphogenesis Roof Of Mouth Development SMAD Protein Signal Transduction
Pathways		Downregulation of ERBB2:ERBB3 signaling Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Asthma ( 31619474)	Refractive error ( 32231278)
Interacting Genes		42 interacting genes: ADRB2 AP2S1 APP ARL6IP4 ASB6 BIRC6 C1orf109 ENOPH1 ERBB3 ERBB4 IRS4 ISCA2 KDM3B LEPR LZTS2 MAGEL2 MARK2 MEOX2 MNAT1 MTNR1A MTNR1B MTURN N4BP3 RAD23A RFC4 RNF166 RRM2B SRR TCEANC TRIM32 TRIM8 TSG101 TTC1 UBASH3A UBASH3B UBE2D3 UBE2K UBE2U UBE2Z USP8 VPS52 ZAP70	1 interacting genes: ACVR2B
Entrez ID		10193	10220
HPRD ID		11520	04895
Ensembl ID		ENSG00000181852	ENSG00000135414
Uniprot IDs		A0A024RB33 Q9H4P4	A0A024RB20 O95390
PDB IDs		2FZP 2GWF	5E4G 5JHW 5UHM 6MAC
Enriched GO Terms of Interacting Partners?
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