PREB and RAB10

Data Source:
BioGRID (affinity chromatography technology)

		PREB	RAB10
Description		prolactin regulatory element binding	RAB10, member RAS oncogene family
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GO Annotations	Cellular Component	Golgi Membrane Nucleus Endoplasmic Reticulum Membrane Membrane Integral Component Of Endoplasmic Reticulum Membrane Endoplasmic Reticulum Exit Site	Golgi Membrane Exocyst Endosome Endoplasmic Reticulum Membrane Golgi Apparatus Trans-Golgi Network Cytosol Cytoskeleton Plasma Membrane Adherens Junction Focal Adhesion Cilium Synaptic Vesicle Cytoplasmic Vesicle Membrane Secretory Granule Membrane Phagocytic Vesicle Membrane Insulin-responsive Compartment Perinuclear Region Of Cytoplasm Recycling Endosome Recycling Endosome Membrane Extracellular Exosome Exocytic Vesicle Endoplasmic Reticulum Tubular Network
	Molecular Function	DNA Binding Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding GTPase Binding	GTPase Activity Protein Binding GTP Binding GDP Binding Myosin V Binding Cadherin Binding Involved In Cell-cell Adhesion
	Biological Process	Regulation Of COPII Vesicle Coating Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Protein Secretion Protein Exit From Endoplasmic Reticulum IRE1-mediated Unfolded Protein Response Positive Regulation Of GTPase Activity COPII Vesicle Coating	Golgi To Plasma Membrane Transport Vesicle Docking Involved In Exocytosis Axonogenesis Protein Secretion Vesicle-mediated Transport Endosomal Transport Regulation Of Exocytosis Antigen Processing And Presentation Polarized Epithelial Cell Differentiation Cellular Response To Insulin Stimulus Golgi To Plasma Membrane Protein Transport Neutrophil Degranulation Regulated Exocytosis Establishment Of Neuroblast Polarity Endoplasmic Reticulum Tubular Network Organization Protein Localization To Plasma Membrane Establishment Of Protein Localization To Membrane Establishment Of Protein Localization To Endoplasmic Reticulum Membrane Cell-cell Adhesion Protein Localization To Basolateral Plasma Membrane
Pathways		COPII-mediated vesicle transport XBP1(S) activates chaperone genes Cargo concentration in the ER	Translocation of SLC2A4 (GLUT4) to the plasma membrane Neutrophil degranulation RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Apolipoprotein B levels ( 32203549) Immune response to smallpox vaccine (IL-6) ( 22542470) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 32888494 27863252) Metabolite levels (HVA) ( 23319000) Metabolite levels (HVA-5-HIAA Factor score) ( 23319000) Metabolite levels (HVA/MHPG ratio) ( 23319000) Platelet distribution width ( 32888494)
Interacting Genes		2 interacting genes: SMAD1 TGFBR1	9 interacting genes: APP ENOPH1 EVI5L MICAL1 MTNR1A PPBP RABIF RIMS1 SEPTIN9
Entrez ID		10113	10890
HPRD ID		16216	06692
Ensembl ID		ENSG00000138073	ENSG00000084733
Uniprot IDs		B5MC98 Q05DB2 Q9HCU5	P61026
PDB IDs		5TF2	5LPN 5SZJ
Enriched GO Terms of Interacting Partners?
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