ARPC2 and ZYG11B

Data Source:
BioGRID (affinity chromatography technology)

		ARPC2	ZYG11B
Description		actin related protein 2/3 complex subunit 2	zyg-11 family member B, cell cycle regulator
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Endosome Cytosol Arp2/3 Protein Complex Focal Adhesion Actin Cytoskeleton Lamellipodium Site Of Double-strand Break Muscle Cell Projection Membrane Neuron Projection Extracellular Exosome Glutamatergic Synapse	Cul2-RING Ubiquitin Ligase Complex
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding Actin Filament Binding	Protein Binding
	Biological Process	Positive Regulation Of Lamellipodium Assembly Actin Filament Polymerization Arp2/3 Complex-mediated Actin Nucleation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Ephrin Receptor Signaling Pathway Membrane Organization Actin Polymerization-dependent Cell Motility Positive Regulation Of Substrate Adhesion-dependent Cell Spreading	Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Pathways		Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation EPHB-mediated forward signaling RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs Clathrin-mediated endocytosis FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis
Drugs		N-[2-(2-methyl-1H-indol-3-yl)ethyl]thiophene-2-carboxamide (2S)-2-(3-bromophenyl)-3-(5-chloro-2-hydroxyphenyl)-1,3-thiazolidin-4-one
Diseases
GWAS		Inflammatory bowel disease ( 28067908 23128233) Mean platelet volume ( 32888494 27863252) Neutrophil count ( 29403010) Obesity-related traits ( 23251661) Platelet count ( 32888494 27863252) Platelet distribution width ( 32888494 27863252) White blood cell count ( 25096241 29403010)	Monocyte percentage of white cells ( 32888494)
Interacting Genes		6 interacting genes: ACTR3 ARPC1B ARPC4 AURKA CORO1B WAS	4 interacting genes: CUL2 ELOB ELOC GBF1
Entrez ID		10109	79699
HPRD ID		10367	13356
Ensembl ID		ENSG00000163466	ENSG00000162378
Uniprot IDs		A0A024R408 O15144 Q53R19	A8DPD7 B4DK95 Q9C0D3
PDB IDs		6UHC 6YW6 6YW7
Enriched GO Terms of Interacting Partners?
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