ACVR1B

Description		activin A receptor type 1B
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Receptor Complex Activin Receptor Complex
	Molecular Function	Protein Serine/threonine Kinase Activity Transmembrane Receptor Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Activin Receptor Activity, Type I Activin-activated Receptor Activity Growth Factor Binding Ubiquitin Protein Ligase Binding Inhibin Binding SMAD Binding Metal Ion Binding Activin Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle In Utero Embryonic Development Hair Follicle Development Regulation Of Transcription, DNA-templated Protein Phosphorylation Signal Transduction Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Nervous System Development Central Nervous System Development Negative Regulation Of Gene Expression Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Peptidyl-threonine Phosphorylation Negative Regulation Of Cell Growth Activin Receptor Signaling Pathway Positive Regulation Of Activin Receptor Signaling Pathway Nodal Signaling Pathway Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Transcription By RNA Polymerase II Development Of Primary Female Sexual Characteristics Protein Autophosphorylation Cellular Response To Growth Factor Stimulus Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Trophoblast Cell Migration
Pathways		Signaling by NODAL Regulation of signaling by NODAL Signaling by Activin
Drugs		ATP Fostamatinib
Diseases
GWAS		Adenocarcinoma ( 26732429) Age-related hearing impairment ( 24939585) Granulocyte count ( 27863252) Hematocrit ( 29403010) Hemoglobin ( 29403010) Lung cancer ( 26732429) Neutrophil count ( 27863252) Post bronchodilator FEV1/FVC ratio ( 26634245) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Urate levels ( 23263486)
Novel Interacting Genes		3 novel interacting genes: SHMT2 TUBA1A TUBA1C
Interacting Genes		22 interacting genes: ACVR2B BAG6 BAMBI BMPR2 FKBP1A IGSF1 INHBA INHBB INHBC NEDD4L NODAL OS9 OTUB1 PRKACB RXRA SMAD2 SMAD4 SMAD7 SNX1 SNX2 TDGF1 TGFBRAP1
Entrez ID		91
HPRD ID		03193
Ensembl ID		ENSG00000135503
Uniprot IDs		P36896
PDB IDs
Enriched GO Terms of Interacting Partners?
Tagcloud ?