PNPT1

Description		polyribonucleotide nucleotidyltransferase 1
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GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Mitochondrial Intermembrane Space Mitochondrial Matrix Endoplasmic Reticulum Membrane Cytosol Polysomal Ribosome Mitochondrial Degradosome
	Molecular Function	3'-5'-exoribonuclease Activity RNA Binding Polyribonucleotide Nucleotidyltransferase Activity Protein Binding Poly(U) RNA Binding Poly(G) Binding MiRNA Binding
	Biological Process	Mitochondrial RNA Catabolic Process Mitochondrial MRNA Catabolic Process Positive Regulation Of Mitochondrial RNA Catabolic Process Mitochondrial RNA 5'-end Processing Mitochondrial RNA 3'-end Processing RNA Catabolic Process MRNA Catabolic Process Cellular Response To Oxidative Stress Cellular Response To Interferon-beta RNA Import Into Mitochondrion RRNA Import Into Mitochondrion Regulation Of Cellular Respiration RNA Polyadenylation Negative Regulation Of Growth Protein Homooligomerization Response To CAMP Response To Growth Hormone Positive Regulation Of MRNA Catabolic Process Protein Homotrimerization Mitochondrion Morphogenesis Nuclear Polyadenylation-dependent MRNA Catabolic Process Mitotic Cell Cycle Arrest RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Mitochondrial MRNA Polyadenylation Liver Regeneration Positive Regulation Of MiRNA Catabolic Process Regulation Of Cellular Senescence
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Drugs
Diseases
GWAS		Autoimmune thyroid disease ( 32581359) Diastolic blood pressure ( 27618452) Glaucoma ( 31959993) Glaucoma (primary open-angle) ( 29891935) Height ( 28552196 25429064 18391951) Intraocular pressure ( 29617998 31959993) Medication use (antiglaucoma preparations and miotics) ( 31015401) Medication use (thyroid preparations) ( 31015401) Optic cup area ( 28073927) Pulse pressure ( 28135244 27841878) Refractive error ( 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Systolic blood pressure ( 27618452) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) Waist circumference adjusted for body mass index ( 28552196)
Novel Interacting Genes		2 novel interacting genes: C2orf74 WDPCP
Interacting Genes		2 interacting genes: ADARB1 HSPB1
Entrez ID		87178
HPRD ID		18493
Ensembl ID		ENSG00000138035
Uniprot IDs		Q8TCS8
PDB IDs		3U1K 5ZF6
Enriched GO Terms of Interacting Partners?
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