SPPL2A

Description		signal peptide peptidase like 2A
Image		No pdb structure
GO Annotations	Cellular Component	Lysosomal Membrane Late Endosome Plasma Membrane Membrane Golgi-associated Vesicle Membrane Late Endosome Membrane Intracellular Membrane-bounded Organelle Extracellular Exosome Integral Component Of Cytoplasmic Side Of Endoplasmic Reticulum Membrane Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane
	Molecular Function	Protein Binding Aspartic Endopeptidase Activity, Intramembrane Cleaving Protein Homodimerization Activity
	Biological Process	Membrane Protein Ectodomain Proteolysis Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Membrane Protein Intracellular Domain Proteolysis Membrane Protein Proteolysis Regulation Of Immune Response
Pathways		Regulation of TNFR1 signaling
Drugs
Diseases
GWAS		Alzheimer's disease (late onset) ( 24162737 30820047) Calcium levels ( 29403010) Chloride levels ( 29403010) Creatinine levels ( 29403010) Fibrinogen ( 23969696) Fibrinogen levels ( 28107422 26561523) General cognitive ability ( 29844566) Glomerular filtration rate ( 29403010) Lymphocyte counts ( 32888494) Monocyte count ( 32888494) Neutrophil count ( 32888494 27863252) Potassium levels ( 29403010) Red blood cell count ( 32888494) Refractive error ( 32231278) Sum basophil neutrophil counts ( 27863252) White blood cell count ( 32888494)
Interacting Genes		2 interacting genes: NFKB1 SGTA
Entrez ID		84888
HPRD ID		09742
Ensembl ID		ENSG00000138600
Uniprot IDs		Q8TCT8
PDB IDs
Enriched GO Terms of Interacting Partners?
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