OBSCN

Description		obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
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GO Annotations	Cellular Component	Cytosol Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction Nuclear Body Myofibril Z Disc M Band Sarcolemma
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Calmodulin Binding ATP Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Structural Constituent Of Muscle Phosphatidylinositol-5-phosphate Binding Ankyrin Binding Titin Binding Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol-3,4-bisphosphate Binding Metal Ion Binding Cell Adhesion Molecule Binding Phosphatidylinositol-4-phosphate Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Protein Phosphorylation G Protein-coupled Receptor Signaling Pathway Multicellular Organism Development Protein Localization To M-band Positive Regulation Of Apoptotic Process Sarcomere Organization Regulation Of Catalytic Activity Regulation Of Small GTPase Mediated Signal Transduction Cell-cell Adhesion
Pathways		NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events
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Diseases
GWAS		Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Estimated glomerular filtration rate ( 31152163) Non-Richardson's syndrome vs Richardson's syndrome in progressive supranuclear palsy ( 30066433) PR interval ( 30046033 32439900)
Interacting Genes		8 interacting genes: ANK1 ANK2 BRCA1 CALM1 DNAJB5 MTDH MYH2 TTN
Entrez ID		84033
HPRD ID		10551
Ensembl ID		ENSG00000154358
Uniprot IDs		A6NGQ3 Q5VST9
PDB IDs		1V1C 2CR6 2DKU 2DM7 2E7B 2EDF 2EDH 2EDL 2EDQ 2EDR 2EDT 2EDW 2ENY 2EO1 2GQH 2MWC 2N56 2YZ8 4C4K 4RSV 4UOW 5TZM 6MG9
Enriched GO Terms of Interacting Partners?
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