EOMES

Description		eomesodermin
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Activating Transcription Factor Binding DNA Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Endoderm Formation Mesoderm Formation Cell Fate Specification Endodermal Cell Fate Specification Heart Looping Adaptive Immune Response CD8-positive, Alpha-beta T Cell Differentiation Involved In Immune Response Regulation Of Transcription By RNA Polymerase II Brain Development Negative Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Cell Differentiation Involved In Embryonic Placenta Development Mesodermal To Mesenchymal Transition Involved In Gastrulation
Pathways
Drugs
Diseases		Polymicrogyria; Bilateral frontal polymicrogyria (BFP); Bilateral frontoparietal polymicrogyria (BFPP); Bilateral perisylvian polymicrogyria (BPP); Bilateral parasagittal parieto-occipital polymicrogyria (BPOP); Bilateral generalised polymicrogyria (BGP); Unilateral Polymicrogyria (ULP)
GWAS		Ankylosing spondylitis ( 23749187) B-cell malignancies (chronic lymphocytic leukemia, Hodgkin lymphoma or multiple myeloma) (pleiotropy) ( 28112199) Chronic lymphocytic leukemia ( 28165464 26956414) Diastolic blood pressure ( 27841878) Epstein Barr virus nuclear antigen 1 IgG levels or multiple sclerosis ( 26819262) Hodgkin's lymphoma ( 24149102) Lymphocyte counts ( 32888494) Macular thickness ( 30535121) Mean arterial pressure ( 29403010) Monocyte count ( 32888494) Multiple sclerosis ( 31604244 22190364 24076602 21833088) PR interval ( 30046033) Pulse pressure ( 29403010) Rheumatoid arthritis ( 30423114 24390342) Rheumatoid arthritis (ACPA-positive) ( 24532676) Systemic lupus erythematosus ( 27399966) Systolic blood pressure ( 29403010) White blood cell count ( 32888494)
Interacting Genes		2 interacting genes: OTP PFDN1
Entrez ID		8320
HPRD ID		07054
Ensembl ID		ENSG00000163508
Uniprot IDs		B7Z4K0 O95936
PDB IDs
Enriched GO Terms of Interacting Partners?
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