TPMT

Description		thiopurine S-methyltransferase
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GO Annotations	Cellular Component	Cytosol
	Molecular Function	Protein Binding Thiopurine S-methyltransferase Activity S-adenosyl-L-methionine Binding
	Biological Process	Nucleobase-containing Compound Metabolic Process Drug Metabolic Process Methylation
Pathways		Methylation Defective TPMT causes Thiopurine S-methyltransferase deficiency (TPMT deficiency)
Drugs		Olsalazine
Diseases		Thiopurine S-methyltransferase deficiency (TPMT deficiency)
GWAS		DNA-incorporated thioguanine levels in 6-mercaptopurine-treated acute lymphoblastic leukaemia ( 30201983) Erythrocyte methylated 6-mercaptopurine metabolite concentration in 6-mercaptopurine-treated acute lymphoblastic leukaemia ( 30201983) Erythrocyte thioguanine concentration in 6-mercaptopurine-treated acute lymphoblastic leukaemia ( 30201983) Thiopurine methyltransferase activity in acute lymphoblastic leukemia patients treated with mercaptopurines ( 27564568) Thiopurine S-methyltransferase activity ( 27770449) Thiopurine-induced myelosuppression in inflammatory bowel disease ( 30806694)
Novel Interacting Genes		2 novel interacting genes: DTNBP1 FGFR1
Interacting Genes		1 interacting genes: APP
Entrez ID		7172
HPRD ID		01760
Ensembl ID		ENSG00000137364
Uniprot IDs		A0A024QZW0 P51580
PDB IDs		2BZG 2H11
Enriched GO Terms of Interacting Partners?
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