TERC

Description		telomerase RNA component
Image		No pdb structure
GO Annotations	Cellular Component	Telomerase Catalytic Core Complex Chromosome, Telomeric Region Telomerase Holoenzyme Complex Cytoplasm Cajal Body Box H/ACA Telomerase RNP Complex
	Molecular Function	Template For Synthesis Of G-rich Strand Of Telomere DNA Activity Telomerase Activity Telomerase RNA Reverse Transcriptase Activity RNA-directed DNA Polymerase Activity Protein Binding Protein-containing Complex Binding DNA Polymerase Binding WD40-repeat Domain Binding
	Biological Process	Telomere Maintenance Via Telomerase Cellular Response To Hypoxia DNA Biosynthetic Process Negative Regulation Of Cellular Senescence
Pathways
Drugs
Diseases		Dyskeratosis congenita (DC), including: X-linked dyskeratosis congenita (DKCX); Autosomal dominant dyskeratosis congenita (DKCA1); Autosomal recessive dyskeratosis congenita (DKCB1)
GWAS		B-cell malignancies (chronic lymphocytic leukemia, Hodgkin lymphoma or multiple myeloma) (pleiotropy) ( 28112199) Bladder cancer ( 24163127) Colorectal cancer or advanced adenoma ( 30510241) Cutaneous malignant melanoma ( 26237428) Glioma ( 28346443) Glioma (high-grade) ( 24908248) Leukocyte telomere length ( 32109421 31171785) Mean corpuscular hemoglobin ( 29403010) Mean corpuscular volume ( 29403010) Multiple myeloma ( 23955597) Nevus count ( 30429480) Nevus count or cutaneous melanoma ( 30429480) Pulse pressure ( 30578418) Systolic blood pressure ( 30578418) Telomere length ( 29151059 23535734 21573004 23900074 20139977 23001564) Thyroid cancer ( 28195142) Uterine fibroids ( 30194396 31649266)
Interacting Genes		2 interacting genes: DKC1 SMN1
Entrez ID		7012
HPRD ID
Ensembl ID		ENSG00000277925
Uniprot IDs
PDB IDs
Enriched GO Terms of Interacting Partners?
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