SLC1A3

Description		solute carrier family 1 member 3
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GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Basal Plasma Membrane Membrane Cytoplasmic Vesicle Neuron Projection Neuronal Cell Body Synapse Perinuclear Region Of Cytoplasm Membrane Protein Complex
	Molecular Function	L-glutamate Transmembrane Transporter Activity High-affinity Glutamate Transmembrane Transporter Activity Protein Binding Glutamate:sodium Symporter Activity Metal Ion Binding
	Biological Process	Neurotransmitter Uptake Ion Transport Chemical Synaptic Transmission Glutamate Secretion L-glutamate Transmembrane Transport L-glutamate Import Transepithelial Transport D-aspartate Import Across Plasma Membrane Potassium Ion Transmembrane Transport L-glutamate Import Across Plasma Membrane L-aspartate Import Across Plasma Membrane Transport Across Blood-brain Barrier Chloride Transmembrane Transport
Pathways		Astrocytic Glutamate-Glutamine Uptake And Metabolism Glutamate Neurotransmitter Release Cycle Transport of inorganic cations/anions and amino acids/oligopeptides Defective SLC1A3 causes episodic ataxia 6 (EA6)
Drugs		Glutamic acid
Diseases		Episodic ataxias
GWAS		Depression in smokers ( 30219690) Heel bone mineral density ( 30598549 28869591) Intraocular pressure ( 29617998) Lumbar spine bone mineral density (integral) ( 27476799) Lumbar spine bone mineral density (trabecular) ( 27476799) Malaria ( 31844061)
Novel Interacting Genes		1 novel interacting genes: RFX3
Interacting Genes		6 interacting genes: BTN2A2 MGST3 SGK1 TMEM120B TMEM128 ZDHHC17
Entrez ID		6507
HPRD ID		02523
Ensembl ID		ENSG00000079215
Uniprot IDs		A0A024R050 A0A087WT87 A0A087X0U3 B4DF14 P43003 Q7Z5T0 Q8N169
PDB IDs		5LLM 5LLU 5LM4 5MJU
Enriched GO Terms of Interacting Partners?
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