ABCG5

Description		ATP binding cassette subfamily G member 5
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GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Apical Plasma Membrane ATP-binding Cassette (ABC) Transporter Complex Receptor Complex
	Molecular Function	Protein Binding ATP Binding ATPase Activity ATPase-coupled Transmembrane Transporter Activity Metal Ion Binding Protein Heterodimerization Activity Cholesterol Transfer Activity
	Biological Process	Response To Nutrient Excretion Response To Ionizing Radiation Negative Regulation Of Intestinal Phytosterol Absorption Response To Muscle Activity Sterol Transport Intestinal Cholesterol Absorption Cholesterol Efflux Bile Acid Signaling Pathway Response To Drug Cholesterol Homeostasis Negative Regulation Of Intestinal Cholesterol Absorption Transmembrane Transport Triglyceride Homeostasis Intermembrane Lipid Transfer
Pathways		ABC transporters in lipid homeostasis Defective ABCG8 causes GBD4 and sitosterolemia Defective ABCG5 causes sitosterolemia NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
Drugs
Diseases		Sitosterolemia
GWAS		C-reactive protein levels or total cholesterol levels (pleiotropy) ( 27286809) Cholesterol, total ( 24097068 19060911 20686565) Coronary artery disease ( 29212778) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) LDL cholesterol ( 24097068 19060911 20686565) Lipid metabolism phenotypes ( 19936222) Metabolite levels (lipoprotein measures) ( 27005778)
Interacting Genes		1 interacting genes: ABCG8
Entrez ID		64240
HPRD ID		05678
Ensembl ID		ENSG00000138075
Uniprot IDs		Q9H222
PDB IDs		5DO7
Enriched GO Terms of Interacting Partners?
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